HOMOCYSTEINE, AN INDEPENDENT CARDIOVASCULAR RISK FACTOR AMONG IRANIAN MALE POPULATION
text
article
2000
eng
Background: Homocysteine is increasingly recognized as a risk factor for coronary artery disease. Research in this field, however, has not produced uniform results. This inconsistency may partly be explained by racial and dietary differences in the studied groups. This study was performed to determine the association between hyperhomocysteinemia and coronary artery disease in Iranian male patients. Methods: 77 consecutive male patients with definite coronary artery disease (doclimented by coronary angiography) who had no conventional major cardiovascular risk factors (smoking, dyslipidemia, hypertension or diabetes mellitus) and 77 healthy controls with the same qualifications were enrolled in the study. Total homocysteine levels were measured by enzyme immunoassay method. Results: There was no significant difference between the ages of cases and controls (mean age±SD: 60.1±10.6 and 59.4±8.4 years in cases and controls, respectively). Mean levels of total homocysteine were 17.9±6.8 and 15.6±6.5 µmol/L in cases and controls, respectively (P=0.038). On logistic regression analysis, the odds ratio for coronary artery disease was found to be 1.67 (95% confidence interval: 1.02-2.75) for each 10µmol/L increment in total homucysteine level. Conclusion: High levels of total homocysteine may be considered an independent risk factor for coronary artery disease in Iranian male population. Further studies are needed to clarify its prevalence and clinical impact.
Iranian Heart Journal
Iranian Heart Association
1
v.
1
no.
2000
6
11
http://journal.iha.org.ir/article_102524_d41d8cd98f00b204e9800998ecf8427e.pdf
RENAL LITHIUM CLEARANCE IN SALT SENSITIVE AND SALT-RESISTANT HYPERTENSIVE PATIENTS
text
article
2000
eng
The relation between dietary sodium intake and hypertension is not a new concept and many epidemiological studies and laboratory findings have demonstrated it, this study investigated blood pressure changes during this regimen. Patients whose mean blood pressure on sixth day of the high-sodium diet exceeded by 13 mmHg or more than that of day six of the low-sodium diet, were classified as "salt-sensitive "and others as "saltresistant" . We determined the lithium clearance to know whether or not there was a correlation between salt-sensitivity without sodium manipulation. Measurements of lithium clearance in these patients confirmed that salt-sensitives had significantly lower lithium clearance (9.27±4.37) than salt-resistants (20.75±9.86) (P<0.05). Since the lithium clearance is a method for assessing tubular sodium and water reabsorption, our results advocate this hypothesis that sodium sensitivity in the hypertensive is related to dysfunction of the proximal tubules, it is predicted that lithium clearance could be used as determinant of salt-sensitivity without sodium manipulation.
Iranian Heart Journal
Iranian Heart Association
1
v.
1
no.
2000
http://journal.iha.org.ir/article_102525_d41d8cd98f00b204e9800998ecf8427e.pdf