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3000 ng/mL). The mean cardiac T2* derived from MRI was 26.58±7.54 ms. The frequencies of the different severities of myocardial iron loading based on myocardial T2* were as follows: 44 (80%) normal, 4 (7.3%) mild, 2 (3.6%) moderate, and 5 (9.1%) severe. MRI T2* did not have a significant correlation with E/A (r=0.091; P=0.508), E′ (r=0.130; P=0.345), E/E′ (r=0.005; P=0.971), and dt (r=0.028; P=0.838). Hepatic iron loading based on the MRI T2* values also did not have any correlation with the echocardiographic indices of left ventricular diastolic dysfunction—namely E/A (r=0.151; P=0.270), E′ (r=0.034; P=0.804), E/E′ (r=0.083;P=0.547), and dt (r=0.128; P=0.351).Conclusions: None of the echocardiographic diastolic function parameters examined in this studywere found to be suitable for cardiac surveillance in transfusion-dependent patients affectedby thalassemia major. Longitudinal studies are needed to evaluate the utility ofechocardiographic and MRI parameters to predict cardiac events. At the moment, we cannotrecommend the replacement of cardiac MR and T2* measurements, indicating myocardialiron loading, by Doppler echocardiography in patients with a normal systolic function.]]>
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