@article { author = {Imantalab, Vali and Seddighinejad, Abbas and Mir Mansouri, Ali and Sadeghi Meibodi, Alimohammad and Dadkhah, Heidar and Farzam, Said and Forghan-Parast, Kambiz}, title = {Effect of Calcium Gluconate on Mean Arterial Pressure after Induction of Anesthesia with Propofol in Patients undergoing Coronary Artery Bypass Graft Surgery}, journal = {Iranian Heart Journal}, volume = {14}, number = {2}, pages = {30-36}, year = {2013}, publisher = {Iranian Heart Association}, issn = {}, eissn = {}, doi = {}, abstract = {Introduction: A combination of Propofol and Fentanyl is used as a method for inducing general anesthesia. Although Propofol is widely used for the induction and maintenance of anesthesia, it has a significant effect on reducing arterial blood pressure. It has been suggested that Calcium Gluconate, when administered simultaneously with Propofol, may reduce the inotrope negative effect of Propofol on heart function.Objective: To determine the effect of Calcium Gluconate in decreasing the negative effect of Propofol.Materials and Methods: This randomized, controlled, double-blind, clinical trial divided 70 patients undergoing elective coronary artery bypass graft surgery (CABG) into two groups: Group A (Calcium Gluconate) and Group B (placebo). Each patient was injected with Fentanyl (4 μg/kg), Pancuronium (0.1 mg/kg), and Propofol (1.5 mg/kg) within 60 seconds via a central vein line. Calcium Gluconate (30 mg/kg) and saline (placebo) were administered to Group A and Group B, respectively. Homodynamic data were obtained at baseline (T0), 4 minutes after anesthesia induction (T1), and 2 minutes after tracheal intubation (T2). The data were analyzed using descriptive statistics, repeated measurement, and T tests; a p value < 0.05 was considered statistically significant.Results: The mean and SD of mean arterial pressure at T0 was 101.11 ± 13.63 for Group A and 107.142 ± 14.59 for Group B (non-significant). These figures for T1 (4 minutes after anesthesia induction) and T2 (2 minutes after tracheal intubation) were 70.14 ± 14.67 and 80.22 ± 23.29 for Group A and 72.05 ± 15.45 and 82.42 ± 14.86 for Group B (non- significant). Conclusion: The findings of this research indicated no differences between the two groups. Calcium Gluconate appeared to exert no impact on reducing the negative effect of Propofol. (Iranian Heart Journal 2013; 13 (2):30-36).}, keywords = {Cardiac Surgery,Calcium Gluconate,Propofol,Fentanyl,blood pressure}, url = {http://journal.iha.org.ir/article_130444.html}, eprint = {http://journal.iha.org.ir/article_130444_e0934f62c8d439c21923258921cde039.pdf} }