%0 Journal Article %T Effects of the Preoperative Administration of a Fibrinogen Concentrate on Bleeding and Transfusion Requirements in Cardiac Surgery %J Iranian Heart Journal %I Iranian Heart Association %Z %A Khalaf-Adeli, Elham %A Babaee, Touraj %A Ghadrdoost, Behshid %A Baghizadeh, Fereshteh %A Alavi, Seyed Mostafa %D 2019 %\ 01/01/2019 %V 20 %N 1 %P 39-44 %! Effects of the Preoperative Administration of a Fibrinogen Concentrate on Bleeding and Transfusion Requirements in Cardiac Surgery %K fibrinogen %K Cardiac Surgery %K transfusion %R %X Background: Contact of blood with the cardiopulmonary bypass (CPB) circuit during cardiac surgeryinduces acquired multifactorial coagulopathy, which results in an increased risk of bleeding andtransfusion requirements. In this study, we investigated the effects of the preoperativeadministration of fibrinogen concentrates on bleeding and transfusion requirements in cardiacsurgery.Methods: Seventy-eight patients scheduled for elective coronary artery bypass graft (CABG) orvalvular surgery were included in this clinical trial between March 2017 and November 2017.The patients were randomly assigned to fibrinogen and control groups. In the fibrinogen group,the patients received 2 g of fibrinogen dissolved in 100 mL of normal saline over a 15-minuteperiod 30 minutes after the induction of anesthesia. In the control group, the patients receivedthe same volume of normal saline during the same period of time. The evaluation of thecoagulation system was performed via thromboelastometry (Rotem device). Postoperativebleeding was recorded as the overall mediastinal drainage or the other drainage at the surgicalsite during a 24-hour period after surgery. The volumes of transfused packed red blood cells,fresh frozen plasma (FFP), and platelet concentrates were recorded.Results: The value of Fibtem-MCF did not show any significant difference between the groups (12.4±4vs 11.7±4 0.46; P=0.46). The mean volume of bleeding was significantly lower in thefibrinogen group than in the control group (168±12 vs 344±37; P=0.001). The mean volume ofthe platelet concentrate used was significantly lower in the fibrinogen group than in the controlgroup (P<0.05). However, there was no significant difference in terms of RBCs and FFPconsumption between the groups.Conclusions: It appears that although preoperative supplementation with fibrinogen has no effect ontransfusion with RBCs and FFP, it results in a reduction in postoperative blood loss and plateletconcentrate requirement during cardiac surgery. %U http://journal.iha.org.ir/article_82791_8a9dde9169ac0b2a0ede8ae7355e5ec4.pdf