TY - JOUR ID - 130444 TI - Effect of Calcium Gluconate on Mean Arterial Pressure after Induction of Anesthesia with Propofol in Patients undergoing Coronary Artery Bypass Graft Surgery JO - Iranian Heart Journal JA - IHA LA - en SN - AU - Imantalab, Vali AU - Seddighinejad, Abbas AU - Mir Mansouri, Ali AU - Sadeghi Meibodi, Alimohammad AU - Dadkhah, Heidar AU - Farzam, Said AU - Forghan-Parast, Kambiz AD - Department of Cardiac Anesthesia, Heshmat Hospital, Rasht University of Medical Sciences, Rasht, IRAN. AD - Guilan University of Medical Sciences, Guilan, IR Iran. Y1 - 2013 PY - 2013 VL - 14 IS - 2 SP - 30 EP - 36 KW - Cardiac Surgery KW - Calcium Gluconate KW - Propofol KW - Fentanyl KW - blood pressure DO - N2 - Introduction: A combination of Propofol and Fentanyl is used as a method for inducing general anesthesia. Although Propofol is widely used for the induction and maintenance of anesthesia, it has a significant effect on reducing arterial blood pressure. It has been suggested that Calcium Gluconate, when administered simultaneously with Propofol, may reduce the inotrope negative effect of Propofol on heart function.Objective: To determine the effect of Calcium Gluconate in decreasing the negative effect of Propofol.Materials and Methods: This randomized, controlled, double-blind, clinical trial divided 70 patients undergoing elective coronary artery bypass graft surgery (CABG) into two groups: Group A (Calcium Gluconate) and Group B (placebo). Each patient was injected with Fentanyl (4 μg/kg), Pancuronium (0.1 mg/kg), and Propofol (1.5 mg/kg) within 60 seconds via a central vein line. Calcium Gluconate (30 mg/kg) and saline (placebo) were administered to Group A and Group B, respectively. Homodynamic data were obtained at baseline (T0), 4 minutes after anesthesia induction (T1), and 2 minutes after tracheal intubation (T2). The data were analyzed using descriptive statistics, repeated measurement, and T tests; a p value < 0.05 was considered statistically significant.Results: The mean and SD of mean arterial pressure at T0 was 101.11 ± 13.63 for Group A and 107.142 ± 14.59 for Group B (non-significant). These figures for T1 (4 minutes after anesthesia induction) and T2 (2 minutes after tracheal intubation) were 70.14 ± 14.67 and 80.22 ± 23.29 for Group A and 72.05 ± 15.45 and 82.42 ± 14.86 for Group B (non- significant). Conclusion: The findings of this research indicated no differences between the two groups. Calcium Gluconate appeared to exert no impact on reducing the negative effect of Propofol. (Iranian Heart Journal 2013; 13 (2):30-36). UR - http://journal.iha.org.ir/article_130444.html L1 - http://journal.iha.org.ir/article_130444_e0934f62c8d439c21923258921cde039.pdf ER -