TY - JOUR ID - 142609 TI - Intravenous Vitamin C to Prevent Contrast-Induced Nephropathy in Patients Undergoing Percutaneous Coronary Intervention JO - Iranian Heart Journal JA - IHA LA - en SN - AU - Futuhi, Farzaneh AU - Malakootian, Mahshid AU - Maleki, Majid AU - Peighambari, Mohammad Mehdi AU - Hosseini Moghadam, Maryam AU - Hosseini, Mohammad Javad AU - Boudagh, Shabnam AU - Arabian, Maedeh AD - Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran. AD - Cardiogenetic Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran. AD - Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran. Y1 - 2022 PY - 2022 VL - 23 IS - 1 SP - 149 EP - 159 KW - Contrast-induced nephropathy KW - Chronic kidney disease KW - Coronary Angiography KW - Vitamin C KW - Antioxidant DO - N2 - Background: This retrospective cohort study aimed to evaluate the effects of the intravenous administration of vitamin C before and after exposure to the contrast medium for the prophylaxis of contrast-induced nephropathy (CIN) in patients undergoing coronary angiography. Methods: Data on 210 patients with chronic kidney disease (CKD) (defined as an estimated glomerular filtration rate ≤60 mL/min/1.73m2) were obtained through medical chart reviews and electronic data in 3 different groups: 1) no vitamin C administered, 2) vitamin C administered 30 minutes before angiography, and 3) vitamin C administered 30 minutes after angiography. Each group consisted of 70 patients, and vitamin C was administered intravenously. CIN incidence in all the groups was defined as an increase of 0.5 mg/dL or 25% in serum creatinine levels. Results: Overall, CIN incidence was significantly lower in patients who received intravenous vitamin C before (P≤0.05) and after (P≤0.05) angiography than in patients with no prophylaxis. The post-angiography administration of vitamin C was very effective in diminishing creatinine rise and preventing CIN. CIN occurred in 7.1% of the patients in the pre-administered and post-administered groups. Conclusions: The intravenous administration of vitamin C before and after angiography could effectively decrease CIN incidence in patients undergoing percutaneous coronary intervention. The post-angiography administration of vitamin C is more effective to decrease serum creatinine levels. (Iranian Heart Journal 2022; 23(1): 149-159) UR - http://journal.iha.org.ir/article_142609.html L1 - http://journal.iha.org.ir/article_142609_4d91b558b54083471948ea7f0da157cf.pdf ER -