TY - JOUR ID - 83520 TI - A DOUBLE-BLIND, PLACEBO-CONTROLLED PARALLEL TRIAL OF VITAMIN C TREATMENT IN MIDDLE AGED PATIENTS (35-50 YEARS OLD) WITH MILD PRIMARY HYPERTENSION JO - Iranian Heart Journal JA - IHA LA - en SN - AU - FOROUD, A AU - FOROUD, AFSAR AD - SHAFA HOSPITAL, KERMAN UNIVERSITY OF MEDICAL SCIENCE, KERMAN IRAN AD - Y1 - 2002 PY - 2002 VL - 3.4 IS - 2.3 SP - 49 EP - 53 KW - systolic blood pressure KW - DIASTOLIC BLOOD PRESSURE VITAMIN C KW - Antioxidant DO - N2 - Objective: An evaluation of the effect of vitamin C on blood pressure is very important because hypertension is a major risk factor for cardiovascular, cerebral and renal diseases.We studied the effect of vitamin C on the blood pressure of patients between 35-50 years old with mild primary hypertension in Kerman.Methods: We conducted a prospective one-year double-blind, placebo controlled parallel trial on 42 middle aged patients with mild primary hypertension at the hypertension clinic in Kerman University of Medical Sciences. Following a 2-week run-in phase, two age and sex matched groups of untreated hypertensive subjects received 8 weeks oral treatment with either vitamin C, 250 mg twice daily (n=21; 8 M/13F, mean age 42.7±5.3 years) or placebo one tablet twice daily (n=21; 10 M/IIF, mean age 42.7± 5.9 years). Blood pressure was measured in the sitting position on three occasions during the run-in phase, and again at 1, 2, 4 and 8 weeks after commencing treatment. Venous blood samples for the measurement of plasma ascorbic acid were measured at baseline and at 1, 2, 4, 8 weeks after treatment.Results: Plasma ascorbic acid level in vitamin C group significantly changed from 8.8±3 umol/l at baseline to 32.3±12 umolll at 8 weeks, but in placebo-treated group, it changed from 13.8±6 umolll at baseline to 9.01±4.1 umolll at 8 weeks during the study period.A more significant fall in mean blood pressure was observed in the vitamin C group than the placebo-treated group such that the mean systolic blood pressure decreased from 153.1± 5 to 144±5.3 mmHg in vitamin C group and from 154.1±4.9 to 149±4.9mmHg in the placebo group. The mean diastolic blood pressure decreased from 95.711.4 to 91.4±1.7 mmHg in the vitamin C group and from 96.2±1.6 to 94.0±1.6 mmHg in the other group.At 8 weeks, the significant difference in the reduction of systolic blood pressure (p<0.05) and diastolic blood pressure (p<0.001) between the two groups became apparent. Conclusion: Vitamin C intake has a useful effect on lowering blood pressure. UR - http://journal.iha.org.ir/article_83520.html L1 - http://journal.iha.org.ir/article_83520_71daec632f93f38d079708af41650de2.pdf ER -