TY - JOUR ID - 83721 TI - EXERTIONAL DYSPNEA AND LEFT ATRIAL MASS JO - Iranian Heart Journal JA - IHA LA - en SN - AU - MOZAFFARI, KAMBIZ AU - YAZDANI BIUCKI, FARZAD, AU - OMRANI, GHOLAMREZA AU - HASHEMI, JAFAR AU - AMINI, AHMAD AD - SURGICAL PATHOLOGY LABORATORY, SHAHEED RAJAIE CARDIOVASCULAR, MEDICAL AND RESEARCH CENTER, MELLAT PARK, VALI ASR AVE., TEHRAN, IRAN AD - Y1 - 2010 PY - 2010 VL - 11 IS - 3 SP - 47 EP - 49 KW - We present a 56-year-old woman who came to the emergency department with an exertional dyspnea of recent onset. A transthoracic echocardiographic examination revealed two round masses in her left atrium with mild mitral stenosis and mild-to-moderate KW - and two creamy-white fleshy tumors were removed. On cross section KW - they were solid and creamy-brown with gritty areas. Histopathological examination showed extensive sheets of round to oval cells KW - and hemangiopericytoma-like patterns. Also KW - multiple lobules of well-differentiated hyaline cartilage were present. An immunohistochemistry (IHC) panel revealed that the chondroid areas were reactive for S100 protein. The round cells expressed CD99 with focal positivity for NSE (neuron-specifi KW - but were negative for the following cytokeratin KW - CD34 KW - Factor VIII KW - actin KW - and desmin. Therefore KW - the cells were mesenchymal in origin with chondroid differentiation KW - and the final diagnosis was a mesenchymal chondrosarcoma. A full-scale investigation into the source of the tumor was unrevealing. Shortly after her discharge from the hospital KW - she developed an embolic cerebrovascular accident DO - N2 - We present a 56-year-old woman who came to the emergency department with an exertional dyspnea of recent onset. A transthoracic echocardiographic examination revealed two round masses in her left atrium with mild mitral stenosis and mild-to-moderate mitral valve regurgitation.Her laboratory data were unremarkable except for a mild anemia. Surgical excision of the masses was performed, and two creamy-white fleshy tumors were removed. On cross section, they were solid and creamy-brown with gritty areas.Histopathological examination showed extensive sheets of round to oval cells, and hemangiopericytoma-like patterns.Also, multiple lobules of well-differentiated hyaline cartilage were present. An immunohistochemistry (IHC) panel revealed that the chondroid areas were reactive for S100 protein. The round cells expressed CD99 with focal positivity for NSE (neuron-specific enolase), but were negative for the following cytokeratin, CD34, factor VIII, actin, and desmin. Therefore, the cells were mesenchymal in origin with chondroid differentiation, and the final diagnosis was a mesenchymal chondrosarcoma.A full-scale investigation into the source of the tumor was unrevealing. Shortly after her discharge from the hospital, she developed an embolic cerebrovascular accident. UR - http://journal.iha.org.ir/article_83721.html L1 - http://journal.iha.org.ir/article_83721_35445cf7a75f9ecc5fdecdab148157a7.pdf ER -