Can Serum Endocan Levels Predict the Presence and Severity of Coronary Artery Ectasia?

Document Type : Original Article


1 Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, IR Iran.

2 Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences and Department of Biochemistry, Afzalipur Faculty of Medicine, Kerman University of Medical Sciences, Kerman, IR Iran.


Background: The aim of this study was to investigate the relationship between serum endothelial cellspecific molecule-1 endocan levels and coronary artery ectasia (CAE).
Methods: This cross-sectional study was conducted on 99 patients. According to angiographic data, the patients were divided into 3 groups: 1) patients with isolated CAE (n = 33), 2) patients with documented coronary artery diseases without CAE (n = 33), and 3) those with normal coronary arteries (n = 33). The endocan concentration was measured via the ELISA technique.
Results: patients with isolated CAE had significantly lower levels of endocan than did the controls (261.30 ± 61.34 vs 564.58 ± 81.69; P < 0.05). There was no significant correlation between endocan levels and the severity of CAE according to the Markis classification (P > 0.05). The patients who used opium had a significantly higher prevalence rate of CAE (65.6% vs 35.3%; P = 0.012). Moreover, in the group with ectasia, by comparison with the non-ectatic group, significantly high levels of serum triglyceride, cholesterol, and LDL levels, as well as low HDL levels, were detected.
Conclusions: Among our study population, a decrease in endocan levels was a sensitive and accurate indicator for predicting the presence of CAE, although the level of this marker was not very effective in determining the severity of ectasia. In addition to a drop in endocan expression levels, the use of opium and also an abnormal lipid profile were the other predictors of CAE.


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