1. Alissa EM, Ferns GA. Heavy metal poisoning
and cardiovascular disease. J Toxicol.
2011;2011:870125.
2. Saeidnia S, Abdollahi M. Toxicological and
pharmacological concerns on oxidative stress
and related diseases. Toxicol Appl Pharmacol.
2013;273:442-55.
3. Kosnett MJ, Wedeen RP, Rothenberg SJ,
Hipkins KL, Materna BL, Schwartz BS, et al.
Recommendations for medical management of
adult lead exposure. Environ Health Perspect.
2007;115:463-71.
4. Glenn BS, Bandeen-Roche K, Lee BK, Weaver
VM, Todd AC, Schwartz BS. Changes in
systolic blood pressure associated with lead in
blood and bone. Epidemiology. 2006;17:538-44.
5. Montezano AC, Touyz RM. Oxidative stress,
Noxs, and hypertension: experimental evidence
and clinical controversies. Ann Med. 2012;44
Suppl 1:S2-16.
6. Bravo Y, Quiroz Y, Ferrebuz A, Vaziri ND,
Rodriguez-Iturbe B. Mycophenolate mofetil
administration reduces renal inflammation,
oxidative stress, and arterial pressure in rats with
lead-induced hypertension. Am J Physiol Renal
Physiol. 2007;293:F616-23.
7. Vaziri ND, Khan M. Interplay of reactive
oxygen species and nitric oxide in the
pathogenesis of experimental lead-induced
hypertension. Clin Exp Pharmacol Physiol.
2007;34:920-5.
8. Li XR, Long YH, Fang X, Liu XG. [Effect of
vitamin C and E on antioxidative enzyme, NOS
activity and NO contents in hippocampus of rats
with lead poisoning]. Zhejiang Da Xue Xue Bao
Yi Xue Ban. 2008;37:189-92.
9. Bagchi D, Swaroop A, Preuss HG, Bagchi M.
Free radical scavenging, antioxidant and cancer
chemoprevention by grape seed
proanthocyanidin: an overview. Mutat Res.
2014;768:69-73.
10. Yonguc GN, Dodurga Y, Adiguzel E,
Gundogdu G, Kucukatay V, Ozbal S, et al.
Grape seed extract has superior beneficial
effects than vitamin E on oxidative stress and
apoptosis in the hippocampus of streptozotocin
induced diabetic rats. Gene. 2015;555:119-26.
11. Badavi M, Mehrgerdi FZ, Sarkaki A, Naseri
MK, Dianat M. Effect of grape seed extract on
lead induced hypertension and heart rate in rat.
Pak J Biol Sci. 2008;11:882-7.
12. Guide to the care and use of experimental
animals [Internet]. Canadian Council on Animal
Care 2017.
13. Guo H, Zhang HF, Xu WQ, Du Q, Zhao J, Ren
LM. Differential effects of short- and long-term
bupivacaine treatment on alpha1-adrenoceptormediated contraction of isolated rat aorta rings
and the reversal effect of lipid emulsion. Acta
Pharmacol Sin. 2015;36:976-86.
14. Rossi E. Low level environmental lead
exposure--a continuing challenge. Clin Biochem
Rev. 2008;29:63-70.
15. Fiorim J, Ribeiro Junior RF, Silveira EA,
Padilha AS, Vescovi MV, de Jesus HC, et al.
Low-level lead exposure increases systolic
arterial pressure and endothelium-derived
vasodilator factors in rat aortas. PLoS One.
2011;6:e17117.
16. Nunes KZ, Nunes DO, Silveira EA, Almenara
Cruz Pereira C, Broseghini Filho GB, Vassallo
DV, et al. Chronic lead exposure decreases the
vascular reactivity of rat aortas: the role of
hydrogen peroxide. PLoS One.
2015;10:e0120965.
17. Chand Basha D, Saya Reddy N, Usha Rani M,
Rajarami Reddy G. Age related changes in
aminergic system and behavior following lead
exposure: protection with essential metal
supplements. Neurosci Res. 2014;78:81-9.
18. Sirivarasai J, Kaojarern S, Chanprasertyothin S,
Panpunuan P, Petchpoung K, Tatsaneeyapant A,
et al. Environmental lead exposure, catalase
gene, and markers of antioxidant and oxidative
stress relation to hypertension: an analysis based
on the EGAT study. Biomed Res Int.
2015;2015:856319.
19. Sivaprakasapillai B, Edirisinghe I, Randolph J,
Steinberg F, Kappagoda T. Effect of grape seed
extract on blood pressure in subjects with the
metabolic syndrome. Metabolism.
2009;58:1743-6.
20. Ottaviani JI, Actis-Goretta L, Villordo JJ, Fraga
CG. Procyanidin structure defines the extent and
specificity of angiotensin I converting enzyme
inhibition. Biochimie. 2006;88:359-65.
21. Alvarez E, Rodino-Janeiro BK, Jerez M,
Ucieda-Somoza R, Nunez MJ, GonzalezJuanatey JR. Procyanidins from grape pomace
are suitable inhibitors of human endothelial
NADPH oxidase. J Cell Biochem.
2012;113:1386-96.
22. Muzi G, Murgia N, Dell'Omo M, Fiordi T,
Sposini F, Argentino A, et al. [Effects of
inorganic lead exposure on the autonomic
nervous system and on the variability of heart
rate among workers at a battery plant]. G Ital
Med Lav Ergon. 2006;27 Suppl 1:46-50.
23. Cohen RA, Tong X. Vascular oxidative stress:
the common link in hypertensive and diabetic
vascular disease. J Cardiovasc Pharmacol.
2010;55:308-16.
24. Byun EB, Sung NY, Yang MS, Song DS, Byun
EH, Kim JK, et al. Procyanidin C1 causes
vasorelaxation through activation of the
endothelial NO/cGMP pathway in thoracic
aortic rings. J Med Food. 2014;17:742-8.
25. Guan T, Di JR, Shang BD. [Effects of lead
exposure on PKC and CaM expression in brains
of prenatal rats]. Zhonghua Lao Dong Wei
Sheng Zhi Ye Bing Za Zhi. 2010;28:693-5.
26. Nour MS, Sarhan NR, Mazroa SA, Gawish SA.
Histological and immunohistochemical study of
cardiac telocytes in a rat model of isoproterenolinduced myocardial infarction with a reference
to the effect of grape seed extract. Acta
Histochem. 2017;119:747-58.
27. Yousef MI, Khalil D, Abdou HM. Neuro- and
nephroprotective effect of grape seed
proanthocyanidin extract against carboplatin and
thalidomide through modulation of
inflammation, tumor suppressor protein p53,
neurotransmitters, oxidative stress and
histology. Toxicol Rep. 2018;5:568-78. doi:
10.1016/j.toxrep.2018.04.006.
28. Pons Z, Margalef M, Bravo FI, Arola-Arnal A,
Muguerza B. Acute administration of single oral
dose of grape seed polyphenols restores blood
pressure in a rat model of metabolic syndrome:
role of nitric oxide and prostacyclin. Eur J Nutr.
2016;55:749-58.