Relationship Between Baseline the WBC Count and the Neutrophil-to-Lymphocyte Ratio and the 6-Month Outcome in Patients With Non–ST-Segment Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention

Document Type : Original Article


1 Cardiovascular Intervention Research Center, Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, IR Iran.

2 Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, IR Iran.


Background: We sought to assess the relationship between the baseline white blood cell (WBC) count and the neutrophil-to-lymphocyte ratio (NLR) and the 6-month outcome in patients with nonST-segment elevation myocardial infarction (NSTEMI) undergoing percutaneous coronary intervention (PCI).
Methods: Between April 2016 and April 2017, consecutive NSTEMI patients who underwent PCI were
prospectively enrolled in a PCI registry. The patients’ demographics, initial WBC count, NLR, and 6-month major adverse cardiac events (MACE) were assessed. The patients were divided into 3 groups based on their WBC count: WBC < 10000, WBC = 1000012000, and WBC > 12000. According to the NLR, there were 3 groups: NLR < 2.5, NLR = 2.54.5, and NLR > 4.5. Finally, the association between these values and 6 months’ MACE was assessed.
Results: The study was conducted on 161 patients with NSTEMI who underwent PCI. The mean age of the participants was 58.9 ± 11 years, and 135 (83.9%) of the patients were male. The results showed that 81.9% of the patients had WBC < 10000, 13.1% had WBC = 1000012000, and 5% had WBC > 12000; additionally, 87 patients had NLR < 2.5, 57 patients had NLR = 2.54.5, and 20 patients had NLR > 4.5. There was no significant association between the time of admission, the WBC count, the number of involved coronary vessels, the reoccurrence of myocardial infarction, unstable angina, atrial fibrillation, cardiogenic shock, and death; nonetheless, there was a significant relationship between the admission NLR and the reoccurrence of myocardial infarction (P = 0.008) and unstable angina (P = 0.02).
Conclusions: The NLR can be considered a predictive parameter for long-term outcomes in NSTEMI patients undergoing PCI.


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