Chest Pain is Associated With Decreased Irisin Serum Levels in Type 2 Diabetic Patients With Coronary Artery Disease

Document Type : Original Article


1 Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, IR Iran.

2 Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences and Department of Biochemistry, Afzalipur Faculty of Medicine, Kerman University of Medical Sciences, Kerman, IR Iran.

3 Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, IR Iran.


Background: This study aimed to determine irisin serum levels in type 2 diabetic patients with and without coronary artery disease (CAD).
Methods: This study was performed on 56 type 2 diabetic patients with and without CAD and 28 normal controls. The serum levels of irisin, HbA1c, and fasting blood sugar of all the participants and the severity of CAD in the diabetic patients were determined.
Results: The irisin serum level was significantly decreased in the CAD diabetic patients who were symptomatic. HbA1c had a moderate positive correlation with the SYNTAX score in the diabetic patients with CAD. The serum level of irisin was not significantly different between the evaluated groups.
Conclusions: Based on the results, decreased irisin may be considered a risk factor for type 2 diabetic patients with CAD. Accordingly, the evaluation of patients with decreased irisin serum levels regarding the prediction of heart infarcts may be valuable.


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