Global Longitudinal Strain of Healthy Iranian Women Aged 20–60 Years

Document Type : Original Article


Department of Cardiology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IR Iran.


Background: Despite the widespread use of different imaging and provocative protocols for heart disease, diagnosis and treatment remain a serious concern. Thus, we aimed to evaluate global longitudinal strain (GLS) among healthy Iranian women aged between 20 and 60 years.
Methods: In this cross-sectional study, 360 healthy Iranian women were enrolled. Transthoracic echocardiography was performed for all the subjects to evaluate GLS and global circumferential strain (GCS). These values were compared between the subjects based on age groups.
Results: The mean GLS and GCS values were −20.95 ± 2.32% and −20.71 ± 1.81%, respectively. GLS and GCS had significant negative correlations with age (r = 0.813, P < 0.001 and r = 0.837, P < 0.001). Moreover, GLS was significantly low in the 50–60 age group (−17.22 ±0.71%) and high in the 20–29 age group (−22.73 ± 1.39%), (P = 0.001). Furthermore, GCS was significantly low in the 50–60 age group (−17.92 ± 0.42%) and high in the 20–29 age group (−21.99 ± 0.86%), (P = 0.001)
Conclusions: In the present study, normal GLS and GCS values were associated with the subjects’ age insofar as normal GLS and GCS ranges were lower in the older age groups, whereas GLS and GCS ranges were higher in the lower age groups (20–29 y). (Iranian Heart Journal 2020; 21(2): 77-83)


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