Opium Addiction is Associated With Increased Damage to Cardiomyocytes: Protective Roles Played by Apelins

Document Type: Original Article

Authors

1 Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, IR Iran.

2 Kerman Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, IR Iran.

Abstract

Background: It has been reported that opium can deteriorate the complications of acute myocardial infarction (AMI). Apelins are molecules whose protective roles against cardiomyocytes have been documented previously. The aim of this study was to evaluate the effects of opium on the serum apelin levels in patients with AMI.
 
Methods: This study was performed on 60 patients with AMI (30 addicted and 30 nonaddicted). The serum levels of apelins, low-density lipoprotein, high-density lipoprotein, triglyceride, cholesterol, total creatine phosphokinase (CPK), and CPK-MB were evaluated using commercial kits.
 
Results: The results showed that although the serum level of apelins was not different between the addicted and nonaddicted patients, it was significantly associated with heart rate and CPK levels in the addicted patients.
 
Conclusions: Considering our results, opium addiction may be associated with increased damage to cardiomyocytes. Additionally, the positive association between apelins and CPK may indicate the protective roles played by these molecules during AMI. (Iranian Heart Journal 2020; 21(3): 6-14)

Keywords


  1. Chan MY, Du X, Eccleston D, Ma C, Mohanan PP, Ogita M, et al., Acute coronary syndrome in the Asia-Pacific region. international Journal of Cardiology, 2016. 202: p. 861-869.
  2. Sepehri ZS, Masoomi M, Ruzbehi F, Kiani Z, Nasiri AA, Kohan F, et al., Comparison of serum levels of IL-6, IL-8, TGF-β and TNF-α in coronary artery diseases, stable angina and participants with normal coronary artery. Cellular and molecular biology (Noisy-le-Grand, France), 2018. 64(5): p. 1-6.
  3. Folino A, Montarolo PG, Samaja M, Rastaldo R. Effects of apelin on the cardiovascular system. Heart failure reviews, 2015. 20(4): p. 505-518.
  4. O'Carroll AM, Lolait SJ, Harris LE, Pope GR. The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis. Journal of Endocrinology, 2013. 219(1): p. R13-R35.
  5. Habata Y, Fujii R, Hosoya M, Fukusumi S, Kawamata Y, Hinuma S, et al., Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1999. 1452(1): p. 25-35.
  6. Lv D, Li H, Chen L. Apelin and APJ, a novel critical factor and therapeutic target for atherosclerosis. Acta Biochim Biophys Sin, 2013. 45(7): p. 527-533.
  7. Gupta MD, Girish MP, Shah D, Rain M, Mehta V, Tyagi S, et al., Biochemical and genetic role of apelin in essential hypertension and acute coronary syndrome. International journal of cardiology, 2016. 223: p. 374-378.
  8. Javadi HR, Allami A, Mohammadi N, Alauddin R. Opium dependency and in-hospital outcome of acute myocardial infarction. Medical journal of the Islamic Republic of Iran, 2014. 28: p. 122.
  9. Roohafza H, Talaei M, Sadeghi M, Haghani P, Shokouh P, Sarrafzadegan N. Opium decreases the age at myocardial infarction and sudden cardiac death: a long-and short-term outcome evaluation. Archives of Iranian medicine, 2013. 16(3): p. 154.
  10. Masoomi M, Azdaki N, Shahouzehi B. Elevated plasma homocysteine concentration in opium-addicted individuals. Addiction & health, 2015. 7(3-4): p. 149.
  11. Malison RT, Kalayasiri R, Sanichwankul K, Sughondhabirom A, Mutirangura A, Pittman B, et al., Inter-rater reliability and concurrent validity of DSM-IV opioid dependence in a Hmong isolate using the Thai version of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA). Addictive behaviors, 2011. 36(1-2): p. 156-160.
  12. Grzywocz P, Mizia-Stec K, Wybraniec M, Chudek J. Adipokines and endothelial dysfunction in acute myocardial infarction and the risk of recurrent cardiovascular events. Journal of Cardiovascular Medicine, 2015. 16(1): p. 37-44.
  13. Sans-Rosello J, Casals G, Rossello X, Gonzalez de la Presa B, Vila M, Duran-Cambra A, et al., Prognostic value of plasma apelin concentrations at admission in patients with ST-segment elevation acute myocardial infarction. Clinical biochemistry, 2017. 50(6): p. 279-284.
  14. Zhang X, Huang LF, Hua L, Feng HK, Shen B. Resveratrol protects myocardial apoptosis induced by ischemia-reperfusion in rats with acute myocardial infarction via blocking P13K/Akt/e-NOS pathway. European review for medical and pharmacological sciences, 2019. 23(4): p. 1789-1796.
  15. Li Y, Quan X, Li X, Pan Y, Zhang T, Liang Z, et al., Kdm6A Protects Against Hypoxia-Induced Cardiomyocyte Apoptosis via H3K27me3 Demethylation of Ncx Gene. Journal of cardiovascular translational research, 2019: p. 1-8.
  16. Liu J, Liu M, Chen L. Novel pathogenesis: regulation of apoptosis by Apelin/APJ system. Acta biochimica et biophysica Sinica, 2017. 49(6): p. 471-478.
  17. Pedrinelli R, Ballo P, Fiorentini C, Denti S, Galderisi M, Ganau A, et al., Hypertension and acute myocardial infarction: an overview. Journal of cardiovascular medicine, 2012. 13(3): p. 194-202.
  18. Reges O, Leibowitz M, Hoshen M, Leventer-Roberts M, Greenland P, Balicer R. Diabetes control: Incidence of acute myocardial infarction and all-cause mortality among patients with 3–6 years’ disease duration. European journal of preventive cardiology, 2017. 24(10): p. 1083-1092.
  19. Bucholz EM, Beckman AL, Kiefe CI, Krumholz HM. Smoking status and life expectancy after acute myocardial infarction in the elderly. Heart, 2016. 102(2): p. 133-139.