Iranian Heart Journal

Iranian Heart Journal

Protective Effects of N-Acetyl Cysteine on Cardiac Function in Diabetic Patients Undergoing Coronary Artery Bypass Grafting

Document Type : Original Article

Authors
Ahmad Reza Salimbahrami 1
Amir Hossein Yazdi 1
Leila Najm Afshar 1
Zahra Mohammadzade-Vizhe 2
Mohammad Hossein Bakhshaei 1
Maryam Farhadian 3
1 Hamadan University of Medical Sciences, Hamadan, IR Iran.
2 Department of Anesthesia, Khatam-ol-Anbia Hospital of Miane, Tabriz University of Medical Sciences, Tabriz, IR Iran.
3 Department of Biostatics, School of Public Health and Research Center for Health Sciences, Hamadan University of Medical Sciences, Hamadan, IR Iran.
Abstract
Background: The preservation of cardiac function in diabetic patients undergoing coronary artery bypass grafting (CABG) would result in improved prognoses in patients. Therefore, in this study, the protective effects of N-acetyl cysteine (NAC) on cardiac function in diabetic patients undergoing CABG were determined.
 
Methods: This triple-blind, randomized, clinical trial study recruited 240 consecutive diabetic patients undergoing CABG in a referral tertiary health-care center, Hamadan, Iran. The patients were randomly assigned (simple random sampling) to receive either NAC or a placebo. In both groups, ischemic preconditioning was developed with a manometer cuff around the arm. The cuff was filled up to 200 mm Hg for 5 minutes before it was emptied to 0 mm Hg for 5 minutes. This technique was repeated 3 times.
 
Results: The mean preoperative ejection fraction (EF) and the preoperative myocardial performance index (MPI) were the same in the 2 groups (P>0.05). The postoperative EF and the MPI were not significantly different between the 2 groups (P>0.05). The trend of changes in the EF and the MPI was not different between the groups (P>0.05).
 
Conclusions: This study demonstrated that NAC in the ischemic preconditioning method did not create a significant effect compared with a placebo, which is in congruence with previous studies in animal models. (Iranian Heart Journal 2021; 22(2): 96-100)
Keywords
N-acetyl cysteine
Cardiac function
Coronary artery bypass
Diabetic patients
Preconditioning
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Iranian Heart Journal
Volume 22, Issue 2
Spring 2021
Pages 96-100