Document Type : Original Article
Department of Emergency Medicine, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran.
Department of Emergency Medicine, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran.
Department of Pathology, School of Medicine, Ahvaz Jundishapur University of Medical sciences, Ahvaz, IR Iran.
Department of Emergency Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran.
Background: Heart failure (HF) is a complex clinical syndrome estimated to have afflicted 23 million people worldwide. This study aimed to measure syndecan-1 and neurotrimin levels in patients with decompensated heart failure (DHF) admitted to the emergency department.
Methods: This study was conducted from November 2017 through June 2018 in Imam Khomeini Hospital, a referral center in Ahvaz, Iran. Baseline demographics were recorded. The Human Syndecan-1/CD138 (SDC1) ELISA kit for the measurement of syndecan 1 and the Human Neurotrimin ELISA kit for the measurement of neurotrimin (ZellBio GmbH, Berlin, Germany) were used. The detection range for syndecan 1 and neurotrimin was 1.5 to 48 ng/mL and 0.4 to 12.8 ng/mL, respectively.
Results: Seventy-two patients met the study inclusion criteria. The mean level of syndecan 1 and neurotrimin was 24.31 ± 8.27 ng/mL (11–37 ng/mL) and 0.52 ± 0.19 ng/mL (0–9 ng/mL), respectively. The results showed no correlations between the severity of illness and syndecan-1 and neurotrimin levels, nor were there any correlations between age, sex, blood urea nitrogen, creatinine, the estimated glomerular filtration rate, and B-type natriuretic peptide (in DHF >500 ng/mL) and the levels of syndecan 1 and neurotrimin (P >0.05).
Conclusions: The syndecan-1 level did not change in patients suffering from HF with reduced ejection fraction (EF). Further, patients in any EF classification had a low level of neurotrimin. However, no significant associations were found between the classes of the EF and the serum neurotrimin level. (Iranian Heart Journal 2021; 22(3): 88-94)