Iranian Heart Journal

Iranian Heart Journal

Association Between Stress-Induced Left Ventricular Diastolic Dysfunction and Ischemic Heart Disease in Myocardial Perfusion Imaging

Document Type : Original Article

Authors
Hadi Malek 1
Nahid Yaghoobi 1
Fatemeh Jalali Zefrei 1
Hassan Firoozabadi 1
Fereidoon Rastgou 1
Hooman Bakhshandeh 1
Ahmad Bitarafan Rajabi 2
Sepideh Hekmat 3
1 Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran.
2 Echocardiography Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran.
3 Shahid Hasheminejad Hospital, Iran University of Medical Sciences, Tehran, IR Iran.
Abstract
Background: Myocardial perfusion imaging (MPI) via gated single-photon emission computed tomography is an effective tool in the evaluation of left ventricular (LV) perfusion and function. The purpose of this study was to determine the association between stress-induced left ventricular diastolic dysfunction (LVDD) and ischemic heart disease (IHD) via MPI.
 
Methods: The present study recruited 103 patients, all of whom underwent a standard 2-day stress/rest gated MPI study according to predefined protocols. Perfusion quantitative and semiquantitative indices and diastolic functional parameters were recorded.
 
Results: The study population comprised 88 male patients (85%) and 15 female patients (15%) at a mean age of 56.3 ± 10.7 years. The thresholds of stress-induced LVDD were calculated as post-stress to rest differences in diastolic parameters and defined as a reduction of 0.21 end-diastolic volumes per second (EDV/s) in the peak filling rate (PFR), an increase of 0.32 in the PFR2/PFR ratio, and an increase of 25 milliseconds of time-to-peak filling. The patients were categorized into 2 groups based on the presence or absence of stress-induced LVDD. The comparison of perfusion parameters depicted no significant changes between the 2 groups (all P-values >0.05). No significant differences were also detected concerning IHD burden (P =0.714).
 
Conclusions: Although LV diastolic dysfunction is deemed one of the earliest indicators of coronary artery disease, we found no significant association between stress-induced LVDD and the burden of IHD. (Iranian Heart Journal 2021; 22(3): 95-103)
Keywords
Myocardial perfusion gated SPECT
Myocardial perfusion imaging
Diastolic dysfunction
Coronary artery disease
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Iranian Heart Journal
Volume 22, Issue 3
Summer 2021
Pages 95-103