Document Type : Original Article
Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran.
Echocardiography Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran.
Shahid Hasheminejad Hospital, Iran University of Medical Sciences, Tehran, IR Iran.
Background: Myocardial perfusion imaging (MPI) via gated single-photon emission computed tomography is an effective tool in the evaluation of left ventricular (LV) perfusion and function. The purpose of this study was to determine the association between stress-induced left ventricular diastolic dysfunction (LVDD) and ischemic heart disease (IHD) via MPI.
Methods: The present study recruited 103 patients, all of whom underwent a standard 2-day stress/rest gated MPI study according to predefined protocols. Perfusion quantitative and semiquantitative indices and diastolic functional parameters were recorded.
Results: The study population comprised 88 male patients (85%) and 15 female patients (15%) at a mean age of 56.3 ± 10.7 years. The thresholds of stress-induced LVDD were calculated as post-stress to rest differences in diastolic parameters and defined as a reduction of 0.21 end-diastolic volumes per second (EDV/s) in the peak filling rate (PFR), an increase of 0.32 in the PFR2/PFR ratio, and an increase of 25 milliseconds of time-to-peak filling. The patients were categorized into 2 groups based on the presence or absence of stress-induced LVDD. The comparison of perfusion parameters depicted no significant changes between the 2 groups (all P-values >0.05). No significant differences were also detected concerning IHD burden (P =0.714).
Conclusions: Although LV diastolic dysfunction is deemed one of the earliest indicators of coronary artery disease, we found no significant association between stress-induced LVDD and the burden of IHD. (Iranian Heart Journal 2021; 22(3): 95-103)