Aneurysms and Aortic Insufficiency: Two Very Rare Complications of Wilson’s Disease

Document Type : Case Report


1 Isfahan Cardiovascular Research Center, Isfahan, IR Iran.

2 Social Determinants of Health Research Center, Lorestan University of Medical Sciences, Khorramabad, IR Iran.


Wilson’s disease is a disorder of copper metabolism that results in the accumulation of copper in various body tissues. The most common organs involved in this disease are the liver and the brain, with most of the clinical symptoms being related to these 2 organs. Albeit less affected, the cardiovascular system is also involved. In this paper, we aim to report a very rare cardiac complication of Wilson’s disease. 1 (Iranian Heart Journal 2021; 22(3): 123-127)


  1. Barbosa ER, Machado AA, Cançado EL, Deguti MM, Scaff M. Wilson's disease: a case report and a historical review. Arquivos de neuro-psiquiatria. 2009 Jun; 67(2B):539-43
  2. Bandmann O, Weiss KH, Kaler SG. Wilson's disease and other neurological copper disorders. The Lancet Neurology. 2015 Jan 1; 14(1):103-13.
  3. Coffey AJ, Durkie M, Hague S, McLay K, Emmerson J, Lo C, Klaffke S, Joyce CJ, Dhawan A, Hadzic N, Mieli-Vergani G. A genetic study of Wilson’s disease in the United Kingdom. Brain. 2013 May 1; 136(5):1476-87.
  4. Zhang YC. Research of hepatolenticular degeneration in the past 10 years. Zhonghua Shen Jing Jing Shen Ke Za Zhi. 1959; 5:326-7
  5. Liu J, Luan J, Zhou X, Cui Y, Han J. Epidemiology, diagnosis, and treatment of Wilson's disease. Intractable & rare diseases research. 2017 Nov 30; 6(4):249-55.
  6. Hlubocka Z, Mareček Z, Linhart A, Kejřová E, Pospíšilová L, Martasek P, Aschermann M. Cardiac involvement in Wilson disease. Journal of inherited metabolic disease. 2002 Jun; 25(4):269-77.
  7. Kuan P. Cardiac Wilson’s disease. Chest. 1987 Apr 1; 91(4):579-83.
  8. Bajaj BK, Wadhwa A, Singh R, Gupta S. Cardiac arrhythmia in Wilson’s disease: An oversighted and overlooked entity!. Journal of neurosciences in rural practice. 2016 Apr; 7(04):587-9.
  9. Grandis DJ, Nah G, Whitman IR, Vittinghoff E, Dewland TA, Olgin JE, Marcus GM. Wilson's disease and cardiac myopathy. The American journal of cardiology. 2017 Dec 1; 120(11):2056-60.
  10. Quick S, Reuner U, Weidauer M, Hempel C, Waessnig N, Mues C, Sveric K, Heidrich F, Reichmann H, Strasser R, Speiser U. 4096Cardiac manifestation in wilson disease. The CARMA Wilson study. A comprehensive clinical and cardiac imaging trial. European Heart Journal. 2017 Aug 1; 38(suppl_1)