Radiation-Induced Valvulopathy

Document Type : Case Report


1 Echocardiography fellowship assistant, department of echocardiography, Rajaie cardiovascular medical and research center,Iran university of medical science

2 MD, FACC, FASE Professor of Cardiology, Echocardiologist, Head of Cardio-Oncology Department and Research Center, Rajaie Cardiovascular Medical & Research Center, Tehran, Iran.

3 department of internal medicine,school of medicine, hematology-oncology and stem cell transplantation research center, Shariati hospital tehran university of medical sciences

4 department of pediatric cardiology,rajaie cardiovascular and medical and research center,iran university of medical science

5 cardiology resident,Rajaie cardiovascular medical and research center,iran university of medical science

6 Cardiology resident,Rajaie cardiovascular medical and research center, Iran university of medical science


Cardiovascular disease and cancer are the 2 leading causes of morbidity and mortality in the world. Radiation to the mediastinum is a key component of treatment for numerous neoplasms, including Hodgkin’s lymphoma and breast cancer. Improvements in oncological treatments have increased the number of survivors, some of whom may suffer from adverse cardiovascular effects due to radiation therapy. 1, 2
The delayed detrimental cardiovascular effects of such radiotherapy protocols have been recognized more recently, largely due to the latency of presentation. 3 Because of the increased life expectancy of these patients, healthcare providers are witnessing an increasing number of long-term side effects of these treatments. Mediastinal radiotherapy is known to cause valvular disease, pericarditis, coronary artery disease, and cardiomyopathy. 4
We herein describe a patient who developed radiation-induced valvulopathy with the typical presentation of radiation-induced heart disease 8 years after a left-sided mastectomy and receiving chemotherapy and radiotherapy for breast cancer. (Iranian Heart Journal 2022; 23(1): 228-232)


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