Iranian Heart Journal

Iranian Heart Journal

Comparison Between the Effect of Albumin and Fresh Frozen Plasma in the Cardiopulmonary Bypass Prime Solution on the Clinical and Laboratory Outcomes of Children Undergoing Congenital Cardiac Disease Surgery

Document Type : Original Article

Authors
Maziar Gholampour Dehaki 1
Farhad Gorjipour 2
Mandana Hosseinzadeh 1
Naser Kachoueian 3
Saeid Heydari nia 1
Ahmad Javanmard 4
1 Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran.
2 Iranian Scientific Society of Extracorporeal Technology, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran.
3 Department of cardiac surgery, Imam Hossein Educational Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
4 Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
Abstract
Background: A decrease in blood oncotic pressure following hemodilution due to cardiopulmonary bypass (CPB) in cardiac surgery results in fluid shift and organ dysfunction. The present comparative study evaluated the effects of adding albumin and fresh frozen plasma (FFP) to the priming solution of a CPB system on clinical and laboratory outcomes in pediatric congenital cardiac surgery candidates.
 
Methods: The present clinical trial study recruited 2 groups of 50 pediatric patients (weight<10 kg) scheduled for the elective surgical repair of congenital heart diseases. The study population was randomly assigned to 2 groups: FFP and albumin. The patients’ hemodynamic parameters, diuresis, chest tube drainage, transfusion, and inotropic drugs, as well as laboratory tests, including the erythrocyte sedimentation rate (ESR), C-reactive protein, blood urea nitrogen, creatinine, lactate, hemoglobin, and hematocrit, were measured as the trial’s primary outcome.
 
Results: ESR was significantly higher in the FFP group (P<0.05). Blood urea nitrogen and creatinine were remarkably lower in the albumin group (P<0.05). No significant differences in hemodynamic variables, the volume of the red blood cell transfusion, the volume of the inotropic infusion, and clinical outcomes were observed between the 2 groups.
 
Conclusions: In patients with FFP in the prime solution, a higher ESR value was observed. While there was no significant difference between the 2 groups regarding hemostasis, albumin offered the advantages of better kidney, liver, and cardiac functions. (Iranian Heart Journal 2022; 23(3): 33-41)
Keywords
Albumin
Cardiac surgery
Cardiopulmonary bypass
Fresh frozen plasma
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Iranian Heart Journal
Volume 23, Issue 3
Summer 2022
Pages 33-41