Evaluation of the Effects of Anabolic Steroids on Right and Left Ventricular Functions in Bodybuilders

Document Type : Original Article

Authors

1 Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, IR Iran.

2 Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, IR Iran.

3 Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences Kerman, IR Iran.

Abstract

Background: Anabolic-androgenic steroids (AASs) misuse for improving exercise ability and muscle mass in bodybuilders is ever-increasing and it is suggested to be responsible for destructive cardiovascular effects. In this study, we sought to assess all structural and functional aspects of left ventricular (LV) and right ventricular (RV) functions in male bodybuilding athletes who consume long-term AASs.
 
Methods: The present study was conducted in Kerman in 2016. Based on a cross-sectional study, 52 bodybuilders were selected and divided into 2 groups (26 cases in each group). As a control group, 20 healthy sedentary volunteers with the same age and body mass index (BMI) as the previous 2 groups were selected.
 
Results: Except for LV end-systolic diameter, LV end-systolic volume, and A/E in the Doppler assessment, there were significant differences between all the parameters of LV structure and function, consisting of LV end-diastolic diameter, interventricular septal diameter, LV posterior wall diameter, LV end-diastolic volume, LV mass, LV mass index, deceleration time in mitral inflow Doppler evaluation, and tissue Doppler imaging (TDI) parameters between AAS users, nonusers, and control groups (all Ps<0.05). Additionally, RV size, fractional area change, tricuspid annular plane systolic excursion, and TDI evaluation of the lateral point of the tricuspid annulus as parameters of RV function were significantly different between the mentioned groups (all Ps<0.05).
 
Conclusions: Our study showed that multiple courses of AAS abuse by young male bodybuilders could lead to detrimental effects on LV and RV morphology and systolic and diastolic functions over time. Therefore, it is essential to raise awareness among young athletes regarding the chronic side effects of these compounds. (Iranian Heart Journal 2022; 23(4): 38-45)

Keywords

References

  1. What are Anabolic stroids? web medical reference from Healthwise, April201
  2. Christion nordquist, what is Anabolic stroid? MNT.Know ledge center ,june 2012
  3. Nova D.Volkow, M.D., Anabolic stroid abuse, National institute on Drug abuse, Augest 2006
  4. HartgensF, Kuipers H: Effects of androgenic anabolic steroids in athletes,outpatient Sportsmodicine and sports medicine center muastricht, 2004; 34(8):513-514
  5. Evans NA: current concepts in anabolic androgenic steroids, the amorican journal of sports medicine, 2004 march 32(2): 534-42
  6. Achar S, Rostamian A , Narayan SM :cardiac and metabolic offects of anabolic – androgenic steroid abuse on lipid and blood pressure , American journal of cordiology 2010 sep, 15; 106(6):893-901
  7. Melnic B, Jansen T, Grabbe S: abuse of anabolic androgenic steroids and bodybulding acne, Journal der deutschen Gesellschaft, 2007 feb; 5(2):110-7
  8. Di luigi, Romonelli F, lenozi A: Androgenic anabolic steroid abuse in male , journal of endocrinological investigation 2005; 28(3suppl) :81-4
  9. Kinderman W:cardiovascular side effects of anabolic androgenic stroids,kardiovaskulare kardiovaskular nebenwir kungen von anabol-androigenen stroiden, 2006 sep; 31(6):566-73
  10. Vanberg P, Atar D: androgonic anabolic steroid abuse and cardiovascular system, handbook of experimental pharmacology 2010; (195):411-57
  11. melchart RB, welder AA: cardiovascular effects of androgenic anabolic steroids, medicine and science in sports and exercise, 1995 sep; 27(9):1252-62
  12. hajimoradi B, Kazerani H: Echocardiographic findings in power athletes abusing anabolic androgenic steroids, Asian journal of sports medicine, 2013 march; 4(1):10-4
  13. arhausen A, Albers T, Kinderman W: Are the cardia effects of anabolic steroid abuse in strength athletes reversible? (British cardiac society), 2004 may, 90(5); 496-501
  14. Ilic I, Dgordjevic v, stankovic I, Vahovic – stipac A, et al: the impact of anabolic and androgenic steroids abuse and type of training on left ventricular remodeling and function in competitive athletes, mortality –medical and pharmaceutical review 2014 Apr; 71(4):383-9
  15. Krieg A, scharhag J, Albeost. Kinderman W, uohausen A: cardiac tissue Doppler in steroid users. International journal of sport medicine 2007 AUG, 28(8):638-43
  16. Andrea A, caso p, salerno G, scalafile R, De corato g, et al: Left ventricular early myocardial dysfunction after chronic misuse of anabolic androgenic steroids :a Doppler Miocardial and strain imaging analysis, British journal of sports medicine 2007 may; 41(3):149-55
  17. Montisci M, El Mazloum R, Cecchetto G, Terranova C, Ferrara SD, Thiene G, et al. Anabolic androgenic steroids abuse and cardiac death in athletes: morphological and toxicological findings in four fatal cases. Forensic science international. 2012; 217(1- 3):e13-e8.
  18. Wu ET, Akagi T, Taniguchi M, Maruo T, Sakuragi S, Otsuki S, et al. Differences in right and left ventricular remodeling after transcatheter closure of atrial septal defect among adults. Catheterization and Cardiovascular Interventions. 2007; 69(6):866-71.
  19. Montisci R, Cecchetto G, Ruscazio M, Snenghi R, Portale A, Viel G, et al. Early myocardial dysfunction after chronic use of anabolic androgenic steroids: combined pulsed-wave tissue Doppler imaging and ultrasonic integrated backscatter cyclic variations analysis. Journal of the American Society of Echocardiography. 2010; 23(5):516-22.
Iranian Heart Journal
Volume 23, Issue 4
October 2022
Pages 38-45

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