COVID-19 Infection Concomitant With Infective Tricuspid Valve Endocarditis

Document Type : Case Report


1 Clinical Research Development Unite of Rouhani Hospital, Babol University of Medical Sciences, Babol, IR Iran.

2 Student Committee Research, Babol University of Medical Sciences, Babol, IR Iran.

3 Heart Research Center, Rajaie Cardiovascular Medical and Research Center, Tehran, IR Iran.


The COVID-19 pandemic, together with its complications and management, has been a significant issue worldwide since March 2020. Concomitant infections in vulnerable patients with preexisting cardiovascular diseases are not uncommon. Sharing information about the diagnostic management and treatment of these comorbidities has a prominent role in unveiling some of this pandemic’s challenges. We herein describe a young adult with a history of implantable cardioverter-defibrillator implantation diagnosed with COVID-19 infection and infective endocarditis. (Iranian Heart Journal 2022; 23(4): 102-108)


  1. Shaobo Shi, MD1,2,3; Mu Qin, MD4; Bo Shen, MD1,2,3; et al. Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China. March 25, 2020. JAMA Cardiol. 2020; 5(7):802-810. doi:10.1001/jamacardio.2020.0950
  2. Khan IH, Zahra SA, Zaim S. At the heart of COVID‐19. J Card Surg. 2020.
  3. Estelle Menu1†, Fre´de´rique Gouriet1,2†, Jean-Paul Casalta and colleagues. Evaluation of empirical treatment for blood culture-negative endocarditis. doi:10.1093/jac/dkw362 J Antimicrob Chemother 2017; 72: 290–298 Advance Access publication 27 September 2016
  4. Enrico Guido Spinoni 1, 2, Anna Degiovanni2 , Francesco Della Corte 1,3, and Giuseppe Patti 1,2. Infective endocarditis complicating COVID-19 pneumonia: a case report. European Heart Journal - Case Reports. Novara, Italy
  5. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, Xiang J, Wang Y, Song B, Gu X, Guan L, Wei Y, Li H, Wu X, Xu J, Tu S, Zhang Y, Chen H, Cao B. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020; 395:1054–1062.
  6. Arnold S. Bayer, Ann F. Bolger, Kathryn A. Taubert, Walter Wilson, James Steckelberg, Adolph W. Karchmer, Matthew Levison, Henry F. Chambers, Adnan S. Dajani, Michael H. Gewitz, Jane W. Newburger, Michael A. Gerber, Stanford T. Shulman, Thomas J. Pallasch, Tommy W. Gage, Patricia Ferrieri. Diagnosis and Management of Infective Endocarditis and Its Complications. 22 Dec 1998
  7. John H. Beigel, M.D., Kay M. Tomashek, M.D., M.P.H., Lori E. Dodd, Ph.D., Aneesh K. Mehta, M.D. Remdesivir for the Treatment of Covid-19 — Final Report. November 5, 2020 N Engl J Med 2020; 383:1813-1826 DOI:10.1056/NEJMoa2007764
  8. Sallard E, Lescure FX, Yazdanpanah Y, Mentre F, Peiffer-Smadja N. Type 1 interferons as a potential treatment against COVID-19. Antiviral Res. 2020 Jun; 178:104791. doi: 10.1016/j.antiviral.2020.104791. Epub 2020 Apr 7. PMID: 32275914; PMCID: PMC7138382.