Document Type : Original Article
Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Department of Physiology and Medical Biochemistry, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Department of Public Health and Preventive Medicine Faculty of Medicine, Airlangga University, Surabaya, Indonesia.
Department of Medical Biology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Background: Heart disease manifestation due to plaque disruption in the coronary arteries is acute coronary syndrome (ACS). Apolipoprotein-E (Apo-E) is a multifunctional protein with central roles in lipid transportation and metabolism. We analyzed the correlation between the Apo-E blood concentration and recurrent ACS.
Methods: This cross-sectional study recruited 90 patients who visited the outpatient cardiology clinic at Airlangga University Hospital. The patients were divided into 3 groups: without ACS, single ACS, and recurrent ACS. The Apo-E blood concentration was measured using the enzyme-linked immunosorbent assay in the Tropical Disease Center of the Airlangga University Laboratory.
Results: The median Apo-E concentration was 3.6 (1.32-14.9) µg/mL in the recurrent ACS group, 4.01 (2.61-18.54) µg/mL in the single ACS group, and 3.95 (1.19-43.51) µg/mL in the group without ACS. The Kruskal-Wallis test showed no differences in Apo-E between the groups. The χ2 test demonstrated no correlation concerning Apo-E between the single ACS and recurrent ACS groups. The Fisher exact analysis showed no correlation between the Apo-E concentration and dyslipidemia.
Conclusions: Our results showed no correlation between the Apo-E concentration and recurrent ACS. (Iranian Heart Journal 2023; 24(4): 63-69)