Relationship Between Cerebral Oximetry Monitoring and Mixed Venous Oxygen Saturation During Cardiopulmonary Bypass and Postoperative Cognitive Impairment

Document Type : Original Article


1 Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran.

2 Nursing Care Research Center, Iran University of Medical Sciences, Tehran, IR Iran.

3 Congenital Heart Disease Research Center, Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, IR Iran.

4 Department of General Surgery, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran.


Background: We assessed the relationship between postoperative cognitive impairment and cerebral oximetry (INVOS) and mixed venous oxygen saturation (SvO2) during cardiopulmonary bypass (CPB).
Methods: This observational cohort study enrolled 110 patients and divided them into 2 groups of 55 subjects. After the exclusion of 5 patients in the SvO2 group and 3 in the INVOS group, the final analysis was conducted on 50 and 52 patients in the former and latter groups, respectively. The Mini-Mental State ‎Examination (MMSE) score was used to assess cognitive impairment in the patients on the second and third postoperative days. SPSS software, version 24, was used for statistical analysis. ‎
Results: On the second postoperative day, the frequency of cognitive dysfunction was 4% in the SvO2 group and 3.8% in the INVOS group ‎‎ (P = 0.73). Three days after surgery, the incidence of cognitive ‎dysfunction in the SvO2 and INVOS groups was 2% and 1.9% (P = 0.49), respectively. No statistically significant difference was observed between the 2 groups concerning the incidence of cognitive dysfunction after surgery with CPB.
Conclusions: Our results indicated that cerebral tissue perfusion monitoring by INVOS could be replaced with the SvO2 approach ‏without increasing the incidence of cognitive dysfunction ‏compared with INVOS in adult cardiac surgery using CPB. (Iranian Heart Journal 2024; 25(1): 66-73)


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