Iranian Heart Journal

Iranian Heart Journal

Comparing the Cardiac Outcomes of Mild and Moderate Hypothermic Cardiopulmonary Bypass in Children Undergoing Congenital Heart Surgery.

Document Type : Original Article

Authors
Mazyar Gholampour-Dehaki 1
Naser Kachoueian 2
Alireza Yaghoobi Golverdi 1
Yaser Toloueitabar 1
Mehran Jafarian 1
Rasool Ferasatkish 1
Behzad Sheikhi 1
Farhad Gorjipour 1
Fazel Gorjipour 3
1 Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran.
2 Department of Cardiac Surgery, Imam Hossein Educational Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
3 Physiology Research Center, Iran University of Medical Sciences, Tehran, IR Iran.
Abstract
Objectives: This single-blind, parallel-design randomized clinical trial aimed to assess the impact of mild and moderate hypothermia on brain oxygenation changes in pediatric patients with noncyanotic cardiac disorders undergoing cardiac surgery.
Methods: In this trial, 68 pediatric patients undergoing noncyanotic cardiac surgery at Rajaie Cardiovascular, Medical, and Research Center were included. Participants were randomly allocated to mild hypothermia (32 ˚C) and moderate hypothermia (28 ˚C) groups. Outcomes were measured and compared between the groups at baseline, during, and after cardiopulmonary bypass.
Results: The mean bypass and cross-clamp times were 147.72±68.30 minutes and 92.03±54.91 minutes, respectively. There were no significant differences between the groups in terms of bypass time, ICU length of stay, and ventilation time. The frequency of neurological complications was also similar between the groups (P>0.05).
Conclusions: The results of this trial demonstrated no significant differences in perioperative and postoperative outcomes, including ICU length of stay, mechanical ventilation time, and neurological outcomes, between the groups managed with mild or moderate hypothermia during cardiopulmonary bypass in noncyanotic pediatric patients undergoing surgery for the correction of congenital heart anomalies. (Iranian Heart Journal 2024; 25(3): 6-15)
Keywords
Mild hypothermia
Moderate hypothermia
Cerebral oxygenation
Cardiopulmonary bypass
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Iranian Heart Journal
Volume 25, Issue 3
Summer 2024
Pages 6-15