Iranian Heart Journal

Iranian Heart Journal

Comparison of Atherosclerotic Risk Factors and Hematologic Parameters Between Coronary Artery Ectasia and Obstructive Coronary Artery Disease

Document Type : Original Article

Authors
Shabnam Boudagh 1
Sorour Ehsani 2
Amir Akbar Fakhrabadi 2
Bahram Mohebbi 3
Ali Zahed Mehr 3
1 Echocardiography Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran.
2 Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran.
3 Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran.
Abstract
Objectives: This study aims to compare atherosclerosis risk factors between patients with coronary artery ectasia (CAE) and those with triple-vessel coronary artery disease (3VD). CAE is characterized by diffuse dilation in epicardial coronary arteries and is associated with risk factors for atherosclerosis.
 
Methods: This retrospective cross-sectional study examined patients who underwent coronary angiography in our center between 2012 and 2016 and were diagnosed with CAE. Patients with 3VD served as the control group. Eligible patients’ medical records were reviewed, and relevant data, including demographic and clinical characteristics, atherosclerotic risk factors, and laboratory and inflammatory markers, were collected and documented.
 
Results: The study population comprised 157 patients with CAE and 156 patients with 3VD. There was a significantly higher proportion of male patients in the 3VD group (P<0.001). Smoking (P<0.001), a history of acute coronary syndromes (P<0.001), and dyslipidemia (P<0.001) were significantly more prevalent in the 3VD group. The mean neutrophil-to-lymphocyte ratio was significantly higher in the 3VD group than in the CAE group (3.6±3.0 vs 2.3±1.9; P<0.001).
Conclusions: The findings of this study suggest that atherosclerosis risk factors and inflammatory markers may play a role in the development of CAE. (Iranian Heart Journal 2024; 25(3): 16-20)
Keywords
Coronary ectasia
Atherosclerosis
Hematologic parameter
  1. Demopoulos VP, Olympios CD, Fakiolas CN, Pissimissis EG, Economides NM, Adamopoulou E, et al. The natural history of aneurysmal coronary artery disease. Heart 1997; 78: 136-41.
  2. Hartnell G, Parnell B, Pridie R. Coronary artery ectasia. Its prevalence and clinical significance in 4993 patients. Heart 1985; 54: 392-5.
  3. Chugh R, Perloff JK, Fishbein M, Child JS. Extramural coronary arteries in adults with cyanotic congenital heart disease. The American journal of cardiology 2004; 94: 1355-7.
  4. Abou Sherif S, Ozden Tok O, Taşköylü Ö, Goktekin O, Kilic ID. Coronary artery aneurysms: a review of the epidemiology, pathophysiology, diagnosis, and treatment. Frontiers in cardiovascular medicine 2017; 4: 24.
  5. Mesquita A, Silva J, Seabra-Gomes R. Coronary artery ectasia: clinical and angiographic characteristics and prognosis. Revista portuguesa de cardiologia: orgao oficial da Sociedade Portuguesa de Cardiologia= Portuguese journal of cardiology: an official journal of the Portuguese Society of Cardiology 1993; 12: 305-10.
  6. Rashid S, Gul U, Ali M, Sadiq T, Kiyani AM. Coronary artery ectasia: clinical and angiographic features. J Coll Physicians Surg Pak 2018; 28: 824-8.
  7. Sarli B, Baktir AO, Saglam H, Arinc H, Kurtul S, Sivgin S, et al. Neutrophil-to-lymphocyte ratio is associated with severity of coronary artery ectasia. Angiology 2014; 65: 147-51.
  8. Swaye PS, Fisher LD, Litwin P, Vignola PA, Judkins MP, Kemp HG, et al. Aneurysmal coronary artery disease. Circulation 1983; 67: 134-8.
  9. Giannoglou GD, Antoniadis AP, Chatzizisis YS, Damvopoulou E, Parcharidis GE, Louridas GE. Prevalence of ectasia in human coronary arteries in patients in northern Greece referred for coronary angiography. The American journal of cardiology 2006; 98: 314-8.
  10. Saglam M, Karakaya O, Barutcu I, Esen AM, Turkmen M, Kargin R, et al. Identifying cardiovascular risk factors in a patient population with coronary artery ectasia. Angiology 2007; 58: 698-703.
  11. Bermúdez P, Martínez-Luengas L. Coronary ectasia: prevalence, and clinical and angiographic characteristics. Revista espanola de cardiologia 2003; 56: 473-9.
  12. Yang J-J, Yang X, Chen Z-Y, Wang Q, He B, Du L-S, et al. Prevalence of coronary artery ectasia in older adults and the relationship with epicardial fat volume by cardiac computed tomography angiography. Journal of geriatric cardiology: JGC 2013; 10: 10.
  13. Sohn C, Kim J, Bae W. The framingham risk score, diet, and inflammatory markers in Korean men with metabolic syndrome. Nutrition research and practice 2012; 6: 246-53.
  14. Ozdemir E, Safak O, AltIn MP, Akgun DE, Emren SV, AvcI E, et al. Correlation Between the Severity of Coronary Artery Ectasia and Monocyte/Lymphocyte, Platelet/Lymphocyte, and HDL/LDL Ratios. Journal of the College of Physicians and Surgeons Pakistan 2020; 30: 235-9.
  15. Qin Y, Tang C, Ma C, Yan G. Risk factors for coronary artery ectasia and the relationship between hyperlipidemia and coronary artery ectasia. Coronary artery disease 2019; 30: 211-5.
  16. Shi S, Qin M, Shen B, Cai Y, Liu T, Yang F, et al. Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China. JAMA cardiology 2020.
  17. Gunes Y, Boztosun B, Yildiz A, Esen AM, Saglam M, Bulut M, et al. Clinical profile and outcome of coronary artery ectasia. Heart 2006; 92: 1159-60.
  18. Almansori MA, Elsayed HA. Coronary artery ectasia–A sample from Saudi Arabia. Journal of the Saudi Heart Association 2015; 27: 160-3.
  19. Kaya H, Ertaş F, İslamoğlu Y, Kaya Z, Atılgan ZA, Çil H, et al. Association between neutrophil to lymphocyte ratio and severity of coronary artery disease. Clin Appl Thromb Hemost 2014; 20: 50-4. doi: 10.1177/1076029612452116
Iranian Heart Journal
Volume 25, Issue 3
Summer 2024
Pages 16-20