1
Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran.
2
Department of Hematology, Faculty of Paramedical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, IR Iran.
3
Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran.
Abstract
Background: Preoperative anemia is associated with increased morbidity and mortality rates among patients undergoing major surgery. This study aimed to investigate the prevalence of preoperative iron deficiency in patients scheduled for cardiac surgery at a cardiovascular medical and research center in Iran.
Methods: This prospective cross-sectional study was conducted at the Rajaei Cardiovascular Medical and Research Center in Iran between October 2018 and September 2019. A total of 165 patients aged 18 years or older who were scheduled for elective cardiac surgery were included. The prevalence of iron deficiency anemia was determined using several iron parameters: serum iron levels, serum ferritin levels, total iron-binding capacity, transferrin saturation, complete blood count, serum blood urea nitrogen levels, serum creatinine levels, and C-reactive protein. Data were collected from patients' medical records.
Results: A total of 165 patients were included in the study, with a male-to-female ratio of 1.3:1. The mean age was 60.6±9.9 years. The prevalence of anemia was 52.1%, higher in women than in men (55.8% vs 44.2%). Iron deficiency anemia was the most common type (75.6%), followed by anemia of chronic disease (15.1%) and other types (9.3%). Iron deficiency anemia was more prevalent in women (60%) than in men (24.7%), whereas anemia of chronic disease was more frequent in men (11.8%) than in women (2.9%).
Conclusions: Our study revealed a high prevalence of anemia among cardiac surgery patients, particularly iron deficiency anemia. These findings emphasize the importance of preoperative anemia screening and management in cardiac surgery settings, which has significant implications for patient care. (Iranian Heart Journal 2024; 25(3): 21-26)
Goodnough LT, Shander A, Riou B. Patient blood management. The Journal of the American Society of Anesthesiologists. 2012; 116(6):1367-76.
Shander A, Hardy J-F, Ozawa S, Farmer SL, Hofmann A, Frank SM, et al. A global definition of patient blood management. Anesthesia & Analgesia. 2022; 135(3):476-88.
Muñoz M, Acheson AG, Auerbach M, Besser M, Habler O, Kehlet H, et al. International consensus statement on the peri‐operative management of anaemia and iron deficiency. Anaesthesia. 2017; 72(2):233-47.
Meybohm P, Westphal S, Ravn HB, Ranucci M, Agarwal S, Choorapoikayil S, et al. Perioperative anemia management as part of PBM in cardiac surgery–a narrative updated review. Journal of cardiothoracic and vascular anesthesia. 2020; 34(4):1060-73.
Walsh TS, Boyd JA, Watson D, Hope D, Lewis S, Krishan A, et al. Restrictive versus liberal transfusion strategies for older mechanically ventilated critically ill patients: a randomized pilot trial. Critical care medicine. 2013; 41(10):2354-63.
Gupta PK, Sundaram A, MacTaggart JN, Johanning JM, Gupta H, Fang X, et al. Preoperative anemia is an independent predictor of postoperative mortality and adverse cardiac events in elderly patients undergoing elective vascular operations. Annals of surgery. 2013; 258(6):1096-102.
Nguyen Q, Meng E, Berube J, Bergstrom R, Lam W. Preoperative anemia and transfusion in cardiac surgery: a single-centre retrospective study. Journal of Cardiothoracic Surgery. 2021; 16:1-8.
Triphaus C, Judd L, Glaser P, Goehring MH, Schmitt E, Westphal S, et al. Effectiveness of preoperative iron supplementation in major surgical patients with iron deficiency: a prospective observational study. Annals of Surgery. 2021; 274(3):e212-e9.
Savarese G, von Haehling S, Butler J, Cleland JG, Ponikowski P, Anker SD. Iron deficiency and cardiovascular disease. European Heart Journal. 2023; 44(1):14-27.
Gupta S, Panchal P, Gilotra K, Wilfred AM, Hou W, Siegal D, et al. Intravenous iron therapy for patients with preoperative iron deficiency or anaemia undergoing cardiac surgery reduces blood transfusions: a systematic review and meta-analysis. Interactive CardioVascular and Thoracic Surgery. 2020; 31(2):141-51.
Geneva S. Organization WH, Haemoglobin Concentrations for the Diagnosis of Anaemia and Assessment of Severity. Vitamin and Mineral Nutrition Information System. Document Reference WHO. 2011. NMH/NHD/MNM/11.1. http://www. who. int/entity/vmnis/indicators/haemoglobin.
Kumar SB, Arnipalli SR, Mehta P, Carrau S, Ziouzenkova O. Iron deficiency anemia: efficacy and limitations of nutritional and comprehensive mitigation strategies. Nutrients. 2022; 14(14):2976.
Bathla S, Arora S. Prevalence and approaches to manage iron deficiency anemia (IDA). Critical Reviews in Food Science and Nutrition. 2022;62(32):8815-28.
Alizadehasl A, Golmohammadi Z, Panjavi L, Mahmoodmoradi S, Azarfarin R. The incidence of anaemia in adult patients with cardiovascular diseases in northwest Iran. JPMA-Journal of the Pakistan Medical Association. 2011; 61(11):1091.
Lim C-H, Kim SW, Kim WC, Kim JS, Cho YK, Park JM, et al. Anemia after gastrectomy for early gastric cancer: long-term follow-up observational study. World journal of gastroenterology: WJG. 2012; 18(42):6114.
Zhao J, Zhu X, Dai Q, Hong X, Zhang H, Huang K, et al. The prevalence and influencing factors of anaemia among pre-pregnant women in mainland China: a large population-based, cross-sectional study. British Journal of Nutrition. 2022; 127(3):439-50.
Sim YE, Wee HE, Ang AL, Ranjakunalan N, Ong BC, Abdullah HR. Prevalence of preoperative anemia, abnormal mean corpuscular volume and red cell distribution width among surgical patients in Singapore, and their influence on one year mortality. PLoS One. 2017; 12(8):e0182543.
Hubert M, Gaudriot B, Biedermann S, Gouezec H, Sylvestre E, Bouzille G, et al. Impact of preoperative iron deficiency on blood transfusion in elective cardiac surgery. Journal of Cardiothoracic and Vascular Anesthesia. 2019; 33(8):2141-50.
Al-Riyami AZ, Baskaran B, Panchatcharam SM, Al-Sabti H. Preoperative anemia is associated with increased intraoperative mortality in patients undergoing cardiac surgery. Oman Medical Journal. 2021; 36(3):e267.
Tanner H, Moschovitis G, Kuster GM, Hullin R, Pfiffner D, Hess OM, et al. The prevalence of anemia in chronic heart failure. International journal of cardiology. 2002; 86(1):115-21.
Ramezani,F. , Khalaf-Adeli,E. and Zadehmehr,A. (2024). Prevalence of Iron Deficiency Anemia in Patients Scheduled for Cardiac Surgery: A Survey at a Cardiovascular Medical and Research Center in Iran. Iranian Heart Journal, 25(3), 21-26.
MLA
Ramezani,F. , , Khalaf-Adeli,E. , and Zadehmehr,A. . "Prevalence of Iron Deficiency Anemia in Patients Scheduled for Cardiac Surgery: A Survey at a Cardiovascular Medical and Research Center in Iran", Iranian Heart Journal, 25, 3, 2024, 21-26.
HARVARD
Ramezani F., Khalaf-Adeli E., Zadehmehr A. (2024). 'Prevalence of Iron Deficiency Anemia in Patients Scheduled for Cardiac Surgery: A Survey at a Cardiovascular Medical and Research Center in Iran', Iranian Heart Journal, 25(3), pp. 21-26.
CHICAGO
F. Ramezani, E. Khalaf-Adeli and A. Zadehmehr, "Prevalence of Iron Deficiency Anemia in Patients Scheduled for Cardiac Surgery: A Survey at a Cardiovascular Medical and Research Center in Iran," Iranian Heart Journal, 25 3 (2024): 21-26,
VANCOUVER
Ramezani F., Khalaf-Adeli E., Zadehmehr A. Prevalence of Iron Deficiency Anemia in Patients Scheduled for Cardiac Surgery: A Survey at a Cardiovascular Medical and Research Center in Iran. Iranian Heart Journal, 2024; 25(3): 21-26.