Iranian Heart Journal

Iranian Heart Journal

Effects of Hydroalcoholic Lavender Extract on Lipid Profiles and Liver Enzymes in Rats Fed a High-Fat Diet

Document Type : Original Article

Authors
Seyed Javad Davari_Sani 1
Seyed Mehdi Beheshti-Nasr 2
Akbar Pejhan 3
Seyedeh Zeinab Seyedi 1
Ali Abedi 4
1 Atherosclerosis Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
2 Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, IR Iran.
3 Cellular and Molecular Research Center, Department of Physiology and Pharmacology, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, IR Iran.
4 Department of Nursing, School of Nursing and Midwifery, North Khorasan University of Medical Sciences, Bojnourd, IR Iran.
Abstract
Background: In light of the antioxidant properties of lavender and the role of antioxidant capacity in blood lipid metabolism and reducing the risk factors for cardiovascular disease, this study aimed to evaluate the effect of hydroalcoholic lavender extract on the lipid profiles of rats fed a high-fat diet (HFD).
 
Methods: In this experimental study, 50 male Wistar rats were randomly divided into 5 equal groups. The rats were fed an HFD daily for 30 days. The first group received a normal diet without the extract. Groups 2 to 5 were administered saline (1 mL/kg) and lavender extract (200, 400, and 600 mg/kg) by oral gavage, respectively, 60 minutes before the HFD daily. Weight change, lipid profiles, and liver enzymes were measured and compared with the relevant control groups. Data analysis was conducted using ANOVA and Tukey's test at a significance level of P < 0.05.
 
Results: HFD feeding led to a significant increase in body weight, plasma lipid profiles, and liver enzymes compared with the control group. Lavender administration significantly decreased TG and TC parameters in the 400 mg/kg (P < 0.05) and 600 mg/kg (P < 0.001) groups compared with the HFD group. The LDL/HDL ratio in the 400 and 600 mg/kg groups significantly decreased compared with the HFD group (P < 0.001). ALP, ALT, and AST levels in the 600 mg/kg group were significantly reduced by 50.5% (P < 0.001), 20.25% (P < 0.001), and 12.34% (P < 0.01) compared with the HFD group, respectively.
 
Conclusions: The results demonstrated that hydroalcoholic lavender extract reduced the lipid profiles and liver enzymes in rats fed an HFD. Consequently, these findings suggest that lavender may possess protective properties against cardiovascular disease. (Iranian Heart Journal 2024; 25(4): 43-50)
Keywords
Lavender
Cardiovascular disease
High-fat diet
Hypercholesterolemia
Hyperlipidemia
Liver Enzymes
Rat
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Iranian Heart Journal
Volume 25, Issue 4
Autumn 2024
Pages 43-50