Iranian Heart Journal

Iranian Heart Journal

Type 2 Myocardial Infarction: Patient Characteristics and Clinical Outcomes

Document Type : Original Article

Authors
1 Cardiology Department, Misr University for Science and Technology College of Medicine, 6th of October, Giza, Egypt.
2 Cardiology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Abstract
Background: Type 2 myocardial infarction (MI) is caused by myocardial ischemia resulting from an imbalance between oxygen supply and demand in the heart. This study aimed to assess the incidence, variations in clinical characteristics, current therapeutic approaches, and overall prognosis in patients with type 2 MI compared to those with type 1 MI.
 
Methods: This prospective, cross-sectional study involved 350 Egyptian patients presenting with MI. Participants were categorized into type 1 MI (n = 262) and type 2 MI (n = 88) groups based on standard diagnostic criteria. Data regarding demographic characteristics, clinical presentations, management strategies, and outcomes, including in-hospital, 30-day, and 6-month mortality rates; major adverse cardiovascular events (MACE); and hospitalization for heart failure, were collected and analyzed.
 
Results: Coronary angiography was performed more frequently in patients with type 2 MI than in those with type 1 MI. Primary percutaneous coronary intervention and coronary artery bypass grafting were more commonly performed in type 1 MI patients. A statistically significant difference was observed between type 1 MI and type 2 MI concerning echocardiographic findings and hospital stays. However, there was no significant difference in MACE at 1-month and 6-month follow-ups, except for mortality and stroke, where a statistically significant difference was found.
 
Conclusions: Type 1 MI is more common than type 2 MI. Nonetheless, type 2 MI is associated with higher mortality rates and longer hospital stays. Patients with type 1 MI typically present with chest pain, while those with type 2 MI predominantly present with dyspnea, syncope, and hemodynamic instability. Cardiac interventions are primarily performed in patients with type 1 MI. (Iranian Heart Journal 2024; 25(4): 51-58)
Keywords

  1. Raphael CE, Roger VL, Sandoval Y, et al. Incidence, Trends, and Outcomes of Type 2 Myocardial Infarction in a Community Cohort. Circulation. Feb 11 2020; 141(6):454-463. doi:10.1161/circulationaha.119.043100
  2. Cediel G, Gonzalez-Del-Hoyo M, Carrasquer A, Sanchez R, Boqué C, Bardají A. Outcomes with type 2 myocardial infarction compared with non-ischaemic myocardial injury. Heart. Apr 2017; 103(8): 616-622. doi:10.1136/heartjnl-2016-310243
  3. Frangogiannis NG. The inflammatory response in myocardial injury, repair, and remodelling. Nat Rev Cardiol. May 2014; 11(5):255-65. doi:10.1038/nrcardio.2014.28
  4. Thygesen K, Alpert JS, Jaffe AS, et al. Fourth Universal Definition of Myocardial Infarction (2018). J Am Coll Cardiol. Oct 30 2018; 72(18):2231-2264. doi:10.1016/j.jacc.2018.08.1038
  5. Saaby L, Poulsen TS, Hosbond S, et al. Classification of myocardial infarction: frequency and features of type 2 myocardial infarction. Am J Med. Sep 2013;126(9):789-97. doi:10.1016/j.amjmed.2013.02.029
  6. Singh A, Gupta A, DeFilippis EM, et al. Cardiovascular Mortality After Type 1 and Type 2 Myocardial Infarction in Young Adults. J Am Coll Cardiol. Mar 10 2020; 75(9):1003-1013. doi:10.1016/j.jacc.2019.12.052
  7. Wereski R, Kimenai DM, Bularga A, et al. Risk factors for type 1 and type 2 myocardial infarction. Eur Heart J. Jan 13 2022;43(2):127-135. doi:10.1093/eurheartj/ehab581
  8. DeFilippis AP, Chapman AR, Mills NL, et al. Assessment and Treatment of Patients With Type 2 Myocardial Infarction and Acute Nonischemic Myocardial Injury. Circulation. Nov 12 2019; 140(20):1661-1678. doi:10.1161/circulationaha.119.040631
  9. Coscia T, Nestelberger T, Boeddinghaus J, et al. Characteristics and Outcomes of Type 2 Myocardial Infarction. JAMA Cardiol. Apr 1 2022; 7(4): 427-434. doi:10.1001/jamacardio.2022.0043
  10. Baron T, Hambraeus K, Sundström J, Erlinge D, Jernberg T, Lindahl B. Type 2 myocardial infarction in clinical practice. Heart. Jan 2015; 101(2):101-6. doi:10.1136/heartjnl-2014-306093
  11. Nestelberger T, Boeddinghaus J, Giménez MR, et al. Direct comparison of high-sensitivity cardiac troponin T and I in the early differentiation of type 1 vs. type 2 myocardial infarction. Eur Heart J Acute Cardiovasc Care. Jan 12 2022; 11(1):62-74. doi:10.1093/ehjacc/zuab039
  12. Gaggin HK, Liu Y, Lyass A, et al. Incident Type 2 Myocardial Infarction in a Cohort of Patients Undergoing Coronary or Peripheral Arterial Angiography. Circulation. Jan 10 2017;135(2):116-127. doi:10.1161/circulationaha.116.023052
  13. López-Cuenca A, Gómez-Molina M, Flores-Blanco PJ, et al. Comparison between type-2 and type-1 myocardial infarction: clinical features, treatment strategies and outcomes. J Geriatr Cardiol. Jan 2016; 13(1):15-22. doi:10.11909/j.issn.1671-5411.2016.01.014
  14. Smilowitz NR, Subramanyam P, Gianos E, Reynolds HR, Shah B, Sedlis SP. Treatment and outcomes of type 2 myocardial infarction and myocardial injury compared with type 1 myocardial infarction. Coron Artery Dis. Jan 2018; 29(1):46-52. doi:10.1097/mca.0000000000000545