Iranian Heart Journal

Iranian Heart Journal

A Study of Dyslipidemia Patterns and the Extent of Coronary Artery Disease

Document Type : Original Article

Authors
Kaleem Ullah sheikh 1
Abeer Sarfaraz 1
Sana Sarfaraz 2
Naheeda Nisar 1
Lubna Mustufa 1
Muhammad Wasiq Anwar 1
1 Department of Cardiology, Liaquat National Hospital and Medical College, Pakistan.
2 Department of Pharmacy and Pharmaceutical Sciences, University of Karachi, Pakistan.
Abstract
Objective: This study aimed to identify dyslipidemia patterns and their correlation with the extent of coronary artery disease (CAD) in patients with a first ST-elevation myocardial infarction (STEMI).
 
Methods: This observational cross-sectional study was conducted from January 2023 through December 2023. A purposive, non-probability sampling technique was used to include 230 consecutive patients who presented to the emergency department of a tertiary care hospital with a primary diagnosis of acute STEMI. Demographics, symptoms, indicators, medical history, medication use, and diagnostic tests performed in the emergency department (e.g., ECG and chest X-rays) were recorded. Laboratory investigations, such as troponin-I and lipid profiles, were also extracted from the database.
 
Findings: The mean age of the study population was 60.39 ± 12.02 years. Of these, 164 (71.3%) patients were male. Multi-vessel disease (including double-vessel and triple-vessel CAD) predominated in the male population. Approximately 30 men in our study had combined hyperlipidemia with triple-vessel disease, followed by 23 men with isolated dyslipidemia and double-vessel disease. The SYNTAX score categories (low, intermediate, and high) demonstrated a statistically significant association with cholesterol levels (P <0.05).
 
Conclusions: We found that the presence of multi-vessel CAD coincided with various patterns of dyslipidemia, and mixed dyslipidemia was the most common pattern observed. (Iranian Heart Journal 2025; 26(4): 15-21)
Keywords
Dyslipidemia
Myocardial infarction
Coronary artery disease
Lipid profile
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Iranian Heart Journal
Volume 26, Issue 4
Autumn 2025
Pages 15-21