Iranian Heart Journal

Iranian Heart Journal

Prognostic Value of Global Longitudinal Strain Measured by 2D Speckle-Tracking Echocardiography in Patients With ST-Segment Elevation Myocardial Infarction

Document Type : Original Article

Authors
Moheb Magdy Mouris Wadie
Ramy Medhat Mitry Ayoup
Ensaf Bassam Yousef Yousef
Ibrahim Elsayed Youssri
Cardiovascular Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Abstract
Background: ST-elevation myocardial infarction (STEMI) is a severe form of coronary artery disease, marked by myocardial necrosis because of complete coronary artery occlusion. Despite advances in treatment, STEMI remains a leading cause of morbidity and mortality globally. Left ventricular systolic dysfunction is a significant predictor of outcomes after STEMI, with global longitudinal strain (GLS) being a promising prognostic marker. This study investigated the prognostic value of GLS measured by speckle-tracking echocardiography (STE) in patients with STEMI treated within 24 hours of onset.
 
Methods: This prospective observational study included 50 hemodynamically stable patients with STEMI (mean age, 56 [SD, 11] years) admitted to Mansoura University for primary percutaneous coronary intervention or thrombolytic therapy. GLS was measured within 48 hours after revascularization. Patients were followed for 6 months to assess major adverse cardiac events (MACE).
 
Results: The median time to presentation was 3 hours, and 69 patients received thrombolytic therapy. Mean ejection fraction was 54 (SD, 8)%, and mean GLS was –11.5 (SD, 3.5). MACE occurred in 24 patients (48%). Diabetes was significantly more common in those with MACE (52% vs 24%; P = 0.044). No significant differences were found in other clinical or laboratory variables. GLS was a significant predictor of adverse outcomes.
 
Conclusions: GLS measured by 2D STE is a valuable prognostic tool in patients with STEMI, providing insight into future cardiac events and functional recovery. (Iranian Heart Journal 2026; 27(1): 52-62)
Keywords
ST-elevation myocardial infarction
global longitudinal strain
speckle-tracking echocardiography
prognostic value
acute myocardial infarction
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Iranian Heart Journal
Volume 27, Issue 1
Winter 2026
Pages 52-62