Iranian Heart Journal

Iranian Heart Journal

Correlation of hs-CRP and the Duke Treadmill Score in the Cardiac Training Test

Document Type : Original Article

Authors
Muhamad Robiul Fuadi
Rinta Prasetiyanti
Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Abstract
Background: Risk stratification is the first step to prevent cardiovascular disease. Cardiac training tests perform it with the Duke Treadmill Score (DTS). The limitations and complications that may occur during cardiac training tests require alternative laboratory examinations. High-sensitivity C-reactive protein (hs-CRP) is an independent predictor of cardiovascular events. This study analyzed the relationship between hs-CRP and the Duke Treadmill Score.
 
Methods: This study has a cross-sectional, observational analytical design. Blood samples were taken from 40 patients who underwent cardiac training at Airlangga University Hospital and Telkom Laboratory in Surabaya, Indonesia. Patients’ hs-CRP levels were measured by TMS 24i Premium Tokyo Boeki in the clinical pathology laboratory of Airlangga University Hospital.
 
Results: The average age of subjects was 43 years. Most subjects were male (60%) and had an increase in low-density lipoprotein cholesterol (92.5%). Hypertension was found in 22.5% of subjects. Most subjects were nonsmokers (70%), had a normal body mass index (82.5%), and did not have diabetic mellitus (82.5%). The mean hs-CRP level was 6.04±9.79 mg/L. DTS results showed -5.13±9.3. There was a correlation between serum hs-CRP and DTS by Spearman analysis (P = -0.85 and P < 0.05).
 
Conclusions: Hs-CRP can be an alternative laboratory examination for stratifying cardiovascular event risks to cover DTS by cardiac training tests. (Iranian Heart Journal 2026; 27(2): 47-53)
Keywords
high-sensitivity C-reactive protein
Duke Treadmill Score
cardiovascular disease
cardiac training test
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Iranian Heart Journal
Volume 27, Issue 2
Spring 2026
Pages 47-53