Association Between 25-Hydroxyvitamin D Levels and the Carotid Intima-Media Thickness

Document Type : Original Article


1 Echocardiography Research Center, Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, IR Iran.

2 Cardiac Primary Prevention Research Center, Department of Cardiology, School of Medical Sciences, Tehran, IR Iran.

3 Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, IR Iran.

4 Shahid Sadoughi University of Medical Sciences, Yazd, IR Iran.

5 Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, IR Iran.


Background: There are insufficient data on the association between the serum level of vitamin D and the carotid intima-media thickness (CIMT). The aim of this study was to investigate the association between the level of serum 25-hydroxyvitamin D and the CIMT. Methods: This cross-sectional study recruited 341 patients. The level of 25-hydroxyvitamin D was measured with radioimmunoassay, and the CIMT was measured with color Doppler ultrasound. Results: The mean serum level of 25-hydroxyvitamin D was 14.88±14.63 ng/mL in the patients with asignificant carotid artery involvement and 17.02±13.56 ng/mL in those without a carotid involvement, with the difference between the 2 groups constituting statistical significance (P=0.034). The prevalence rate of vitamin D deficiency in those with and without a carotid involvement was 88.6% and 74.4%; the rate was significantly higher in the former group (P=0.039). Conclusions: Our study confirmed recent suggestions regarding the association between vitamin D deficiency and the progress of atherosclerosis in carotid arteries as CIMT.


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