Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, IR Iran
Cardiovascular Intervention Research Center, Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, IR Iran
Background: Clarification is needed as regards the relationship between the total bilirubin level and
the outcome of primary percutaneous coronary intervention (PCI) in patients with ST-segment
elevation myocardial infarction (STEMI).
Methods: Between April 2015 and April 2016, consecutive patients with STEMI who underwent
primary PCI were prospectively enrolled in a primary PCI registry. The patients’ demographics,
initial total bilirubin levels, procedural characteristics, and in-hospital and 6 months’ major
adverse cardiac events were assessed.
Results: A total of 95 patients who underwent primary PCI were enrolled in the study. The mean
bilirubin level was 1.04 mg/dL with a standard deviation of 1.154. We evaluated the
relationships between the median of the initial total bilirubin level, the thrombolysis in
myocardial infarction (TIMI) flow grade after PCI and following PCI, 6 months’ follow-up
complications, the amount of the peak troponin and CK-MB levels, the amount of mitral
regurgitation, the ejection fraction, and electrocardiographic changes including ST resolution
and the Q-wave formation after primary PCI. Except for the levels of troponin and CK-MB,
there were no relationships between the initial total bilirubin level and the other end points.
Conclusions: Recent studies have shown that the serum total bilirubin level is independently associated
with short-term outcomes in patients with STEMI. We found a direct relationship between the
total bilirubin level and the peak levels of troponin and CK-MB after primary PCI. This
outcome is consistent with other studies; nonetheless, we found no such relationships vis-à-vis
the other end points. This result may be due to our small patient population.