Authors
1
Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, IR Iran
2
Echocardiography Research Center, Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, IR Iran
3
Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, IR Iran.
Abstract
Background: Tissue iron deposition is an important adverse effect in patients with major thalassemia,
leading to right-sided heart failure. This study was performed to determine the association
between cardiovascular magnetic resonance using T2-weighted sequences (CMR T2*) and
advanced echocardiographic right ventricular (RV) function criteria in patients with major
thalassemia at Rajaie Cardiovascular, Medical, and Research Center in 2014 and 2015.
Method: This comparative study assessed the association between CMR T2* and advanced
echocardiographic RV function criteria in 38 patients with major thalassemia at Rajaie
Cardiovascular, Medical, and Research Center in 2014 and 2015.
Results: CMR T2* was correlated with the RV E/E’ (echo) (P = 0.0001, r = -0.681), TAPSE (echo)
(P = 0.001, r = 0.504), RVEDV (CMR) (P = 0.008, r = 0.425), and RVEDV/BSA (CMR)
(P = 0.005, r = 0.443) according to the Spearman test. Additionally, CMR T2* was associated
with the basal RV Sm (echo) (P = 0.0001, r = 0.626), RV strain (echo) (P = 0.034, r = 0.382),
RVEDV/H (CMR) (P = 0.002, r = 0.483), LVEDV (CMR) (P = 0.022, r = 0.372), and
LVEDV/H (CMR) (P = 0.017, r = 0.385) according to the Pearson test.
Conclusions: Totally, according to the obtained results, it may be concluded that the RV E/E’, TAPSE,
basal RV Sm, and RV strain from echocardiography and the RVEDV, RVEDV/BSA,
RVEDV/H, LVEDV, and LVEDV/H from CMR may be indicators of myocardial iron overload
in patients with major thalassemia.
Keywords
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