Cardiovascular Intervention Research Center, Rajaie Cardiovascular, Medical, and Research Center; Iran University of Medical Sciences, Tehran, IR Iran
Rajaie Cardiovascular, Medical, and Research Center; Iran University of Medical Sciences, Tehran, IR Iran
Echocardiography Research Center, Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, IR Iran
Background: The presence of pericardial effusion (PE) in the setting of infective endocarditis (IE) may
be a sign of more severe IE. In this study, we aimed to determine the prevalence and prognostic
significance of PE in patients with native valve IE.
Methods: The Iranian Registry of Infective Endocarditis (IRIE) is a single-center observational
hospital-based study of patients with IE. Between 2002 and 2015, all patients with a diagnosis
of IE who had been enrolled in the IRIE were evaluated.
Results: A total of 445 patients (68.3% male) were enrolled in this registry, and 221 (49.7%) patients
had PE. PE was more prevalent in the patients with native valve IE and those with right-heart
involvement (65% in right-heart IE vs 50% in left-heart IE; P=0.002). The rate of in-hospital
mortality was 20% and 19.2% in the patients with and without PE, respectively, and the
presence of PE was not a predictor of in-hospital death in our multivariate analyses.
Additionally, there was no relationship between the rates of IE-related complications and the
severity of PE. However, the prevalence of PE was higher in the patients with right-sided IE as
well as in those with aortic root abscess and systemic emboli at presentation.
Conclusions: The prevalence of PE in the setting of IE was relatively high in the present study. Most
cases of PE had mild effusion, and there was no relationship between the severity of PE and IErelated complications as well as in-hospital mortality.