Background: An elevation in the levels of troponin I and T is more frequent than a rise in CK-MB levels after percutaneous coronary intervention (PCI). Nevertheless, the prognostic value of elevated troponin I and T levels has yet to be compared with that of elevated CK-MB levels. Given the more specific role of troponin in cardiac incidents, we sought both to investigate the factors and elevated levels of cardiac troponin in patients having undergone PCI and to examine the predictive value of elevated cardiac troponin levels in comparison with that of elevated levels of CK-MB. Methods: This case-series study was conducted in Rajaie Cardiovascular, Medical, and Research Center in 2011. The inclusion criteria comprised patients with coronary artery disease and stable hemodynamic who were ively candidated for nonemergency coronary angiography in the hospital. Five hundred patients were included via convenient sampling within a year. Troponin and CK-MB levels were checked after PCI. In data analysis, the t- test, χ2 test, and Fisher exact test were used. The results were analyzed using SPSS, version 17. Results: The troponin level was elevated in 26.8% of the patients following PCI. The troponin assay was negative and positive in 73.2% and 26.8% of the patients, respectively. The mean age of the patients was 56.6 ± 9.9 years (71.8% male and 28.2% female). Totally, 68.2% of the patients’ lesions were non-C patent type. There was a significant relationship between increased levels of troponin I and re-PCI (1 year after PCI) and also between gender and troponin elevation. Serum troponin was higher in the male patients after PCI. Conclusions: A significant relationship was observed between elevated troponin I levels and redo- PCI a year after PCI. Increased levels of troponin I following PCI were not correlated with major cardiac events. (Iranian Heart Journal 2017; 18(3):13-20)