Correlation between Post Percutaneous Coronary Intervention CKMB Elevation and One-Year Major Adverse Cardiac and Cerebrovascular Events


1 Department of Cardiology,Ekbatan Hospital, Hamedan University of Medical Sciences,Hamedan, I.R.Iran.

2 Department of Cardiology,Ekbatan Hospital, Hamedan University of Medical Sciences,Hamedan, I.R.Iran


Background:CKMB elevation after percutaneous coronaryintervention (PCI) correlates with major adverse cardiac and cerebrovascularevents(MACCE). There is, however, some controversy over this issue, with some studies having reported different conclusions. We assessed the correlation betweentheCKMB level afterPCI and one-year MACCE incidence in these patients. Methods:We measured the CKMB level before and after PCI in 221 patients with normal baseline CKMB who underwent PCI at Ekbatan University Hospital, Hamedan, Iran,between April 2013and October 2013,and divided them into 4groups based on the post-PCICKMB level. Then, we evaluated one-year MACCE incidence.Results:CKMB elevation was detectedin 81 (37.6%) patients and MACCEoccurred in 11 (5%) patients. CKMB elevation after PCI was correlated toMACCE. The predictors of CKMB elevation were hyperlipidemia, number of deployed stents, stent diameter≥4mm,and complicated PCI.Conclusions:CKMB elevation after PCI was detected in 37.6% of the study populationand wascommon in the setting of hyperlipidemia, more than 1stent deployment,stent diameter ≥4mm,and complicated PCI. MACCE at 1year occurred in 5% of the patients and was correlated with the post-PCI CKMB level ≥3 times ofnormal, history of diabetes mellitus, history of hypertension,and inappropriateuse ofclopidogrel.(Iranian Heart Journal 2015; 16(4): 41-46)