THE EFFECT OF PRIMARY BOLUS DOSE OF PANCURONIUM VERSUS CISATRACURIUM WITHOUT MAINTENANCE DOSE ON EXTUBATION TIME IN ADULT CORONARY ARTERY BYPASS GRAFTING

Authors

1 1Assistant Professor, Cardiac Anesthesiology Dept. Shahid Rajaei Cardiovascular, Medical and Research Center, Tehran, Iran

2 Fellowship in Cardiac Anesthesiology, Cardiac Anesthesiology Dept. Shahid Rajaei Cardiovascular, Medical and Research Center, Tehran, Iran

3 3Associate Professor, Fellowship in Cardiac Anesthesiology, Anesthesiology Research Center and Anesthesiology Dept, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Abstract

Background: Given the importance of the effect of muscle relaxants on the extubation time in coronary artery bypass grafting (CABG) patients, we sought to assess the difference in "time to extubation" and "intensive care unit (ICU) length of stay" between the primary bolus doses of Pancuronium and Cisatracurium without using the maintenance dose of them during surgery.
Methods: This double blind clinical trial divided 110 patients into two equal groups receiving either Cisatracurium or Pancuronium. The patients’ surgical and cardiopulmonary bypass variables were evaluated, and the extubation time and ICU length of stay were compared between the two groups.
Results: There was no difference between the two groups regarding the depth of anesthesia, train-offour (TOF) scores at the beginning of anesthesia, and the surgical and cardiopulmonary bypass variables. However, the Cisatracurium patients were extubated earlier and had a shorter ICU length of stay than the Pancuronium patients.
Conclusion: An appropriate depth of anesthesia facilitates the administration of the induction dose of Cisatracurium, which confers earlier extubation and shorter ICU length of stay by comparison with Pancuronium.

Keywords

Iranian Heart Journal
Volume 12, Issue 1
March 2011
Pages 22-26

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