Shahid Rajai Cardiovascular Medical Center,Vali-Asr St.,Park Mellat,Tehran, Iran.
Abstract
Objective: This study evaluated the correlation between human leukocyte antigens and rheumaticheart disease in Iranian population. Background; Rheumatic fever and chronic rheumatic valvular heart disease are one of the major public health.problems in this country,as well as in most of the developingcountries. Methods: The distribution of human leukocyte antigens was evaluated in 92 rheumatic valvular heart disease patients. Class I (A, 13and C) and class n (DR and DQ) antigenswere studied in 92 patients and comparedwith 200 normal subjects. Results: This study showed significantcorrelations between rheumatic heart disease and DQW2 antigen, (57.4% versus 19%, p<0.0001) as well as DRW53 (47.5% versus 8.5%, p<0.0001) and A24 (31.2% versus 13.3%,p<0.005). Conclusion: Human leukocyte antigens (DQW2, DRW53 and A24) are more ftequent in rheumatic valvular heart disease than normal population and could be.markers for more susceptibilityto rheumatic heart diseasein Iranianpopulation.
MOMTAHEN, M., GHORBANI, H., MALEKL, M., & MOMTAHEN, A. (2000). HUMAN LEUKOCYTE ANTIGENS AND RHEUMATIC HEART DISEASE. Iranian Heart Journal, 1(2), 117-122.
MLA
M MOMTAHEN; H GHORBANI; M MALEKL; A.J MOMTAHEN. "HUMAN LEUKOCYTE ANTIGENS AND RHEUMATIC HEART DISEASE". Iranian Heart Journal, 1, 2, 2000, 117-122.
HARVARD
MOMTAHEN, M., GHORBANI, H., MALEKL, M., MOMTAHEN, A. (2000). 'HUMAN LEUKOCYTE ANTIGENS AND RHEUMATIC HEART DISEASE', Iranian Heart Journal, 1(2), pp. 117-122.
VANCOUVER
MOMTAHEN, M., GHORBANI, H., MALEKL, M., MOMTAHEN, A. HUMAN LEUKOCYTE ANTIGENS AND RHEUMATIC HEART DISEASE. Iranian Heart Journal, 2000; 1(2): 117-122.
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