Mellat Park, Vali Asr Avenue, Tehran, Iran
Background- This study was designed to investigate whether isolated genetic factors, controlled by genes in the HLA chromosomal region, could be indicated as independent contributing influences in genesis of coronary artery disease (CAD).
Methods and Results- Twenty-four patients with fixed obstructive CAD documented by coronary angiography had no coronary risk factors with respect to age, levels of serum cholesterol, fasting TG, blood glucose, blood pressure, obesity, a history of diabetes mellitus or hypertension, cigarette smoking history, left ventricular hypertrophy, and abnormal body mass index. 4 patients also had a positive family history of CAD. HLA typing was limited to antigens of DR & DQ loci.
Control subjects (n = 12) were normal. As our sample volume was low, the analysis was not meaningful; therefore we accepted meaningful as 0.1. At DR1, DR2, DR3, DR7, DR10, DR14, DR15, DQ1, DQ2 loci, no antigens demonstrated an observed frequency significantly higher than that expected from the control population. At DR4, DR11, DQ3 loci had significantly greater frequency (45.5%, 37.5%, and 70.8%) with p values that were 0.086, 0.069, 0.02 respectively in the study group with CAD than in the control population (16.7%, 8.3%, 41.7%) with odds ratios of 4.23, 6.6, 3.4 for CAD if the patient had an antigen respectively.
Conclusions- Our data suggest a statistically significant trend between the presence of HLA - DR4, DR11 and DQ3 and CAD