Background- Nitroglycerin in sublingual form is an established therapy for the treatment of angina. Sublingual TNG spray has been widely used in Europe and North America for several years. This study is conducted to compare another preparation, Nitromint^R spray, with a standard preparation (Nitrolingual^ R spray) in our population.
Methods- Sixty coronary artery disease (CAD) patients, documented by angiography, noninvasive stress tests or previous history of MI, completed this randomized clinical trial for the comparison of efficacy and safety of Nitromint^R spray and Nitrolingual^R spray.
Results- There was no significant differences in the duration of symptoms, dose numbers and the time of relief of the symptoms. Also, no significant differences were noted in the frequencies and types of adverse effects.
Conclusion- Nitromint^R spray is as effective and safe as NitrolingualR spray for the treatment of symptomatic coronary artery disease (Iranian Heart Journal 2003; 4 (2, 3): (39-42).