DETERMINATION OF PENICILLIN MIC AND MBC ON STREPTOCOCCUS HA, PREVALENCE OF STREPTOCOCCAL PHARYNGITIS AND HEALTHY CARRIER RATE

Objectives- Prompt diagnosis and appropriate treatment of streptococcal pharyngitis ‎is essential for prevention of acute rheumatic fever (ARF) as the most dangerous ‎complication of beta hemolytic group A streptococcus (Sb#HA) pharyngitis and the ‎most common cause of acquired heart disease. As part of the National Project for ‎Primary Prevention of Acute Rheumatic Fever (PPORF), this study was performed to ‎determine the prevalence of Sb#HA pharyngitis, the healthy carrier rate and the MIC ‎‎(minimum inhibitory concentration) and the MBC (minimum bactericidal ‎concentration) of penicillin on streptococcus BHA
‎ Methods- This descriptive and cross-sectional survey studied more than 1000 students ‎and patients aged 5-15 years, selected randomly for the determination of S,BHA ‎pharyngitis prevalence and healthy carrier rate. Additionally, part of this research was ‎experimental and interventional with the aim of determining the MIC and MBC of ‎penicillin on S,b#HA, in the throat of patients and healthy carriers.
‎ Results- According to the results, 20% of all sore throats were streptococcal ‎‎(S,b#HA), healthy carrier rate was 4.7%, penicillin MBC was 125-0.060 u/ml and ‎penicillin MIC was 31.85-0.03 u/ml.
‎ Conclusion- Penicillin MBC and MIC in this study showed resistant streptococcal ‎species in 15% and tolerant species in 11 % of cases (Iranian Heart Journal 2003; 4 ‎‎(2,3): SS-58).‎