TEHRAN HEART CENTER, NORTH KARGAR AVE, TEHRAN, IRAN
Background- Patients with coronary artery disease have a predilection for the development of remote atherosclerosis and may be expected to be at greater risk of renal artery stenosis. This study assesses the patients with high suspicion of coronary artery disease who have high blood pressure (>140/90 mmHg) in spite of treatment with anti-ischemic drugs (combination of beta-blocker, calcium channel blocker and nitrate).
Methods- The severity of renal and coronary stenoses were quantified in 57 patients (mean age 52.3 ± 3.5 y) with evidence of coronary artery disease and high blood pressure who were on anti-ischemic drug therapy. These patients underwent selective or nonselective renal artery angiography as part of a diagnostic cardiac catheterization study at our center between March 1999 and March 2002.
Results- Coronary artery disease was seen in 82.5% of these patients, which was significant (>50%) in 66.7% of them. Renal artery stenosis of any degree was seen in 42% of the patients. 28% of the patients had significant (50%) renal artery stenosis. There was a good correlation between the severity of coronary and renal artery stenoses (p=0.016). Also, there was a correlation between the number of involved coronary and renal arteries (p=0.019).
Conclusions- In patients with clinical evidence of coronary artery disease who have high blood pressure in spite of treatment with combined anti-ischemic drug therapy, renal artery study during cardiac cathetreization is a logical and useful decision (Iranian Heart Journal 2002, 2003; 3(4)& 4(1): 21-24).