Background- Similar to the view that women are protected against cardiovascular disease because of estrogen, it has been assumed that the increased incidence of cardiovascular disease in men is in part related to androgen levels. However, studies designed to examine this link have instead suggested that testosterone has a neutral or perhaps even beneficial effect on cardiovascular disease in men. It is this relationship that we studied.
Methods- Ninety male subjects (60 with positive and 30 with negative coronary angiograms) were recruited. Early morning fasting blood samples were taken from each patient and total testosterone, total estradiol, sex hormone binding globulin and lipids were measured and free testosterone index (FTI) was calculated.
Results- Men with proven coronary artery disease had higher levels of total cholesterol, triglycerides and low density lipoprotein (LDL) and a lower level of high density lipoprotein, but this was only statistical significant for total cholesterol and LDL, (p=0.004). Men with coronary artery disease had lower levels of serum total testosterone, estradiol and free testosterone index but this difference did not reach statistical significance.
Conclusion-Considering the results of this study, we conclude that serum testosterone and estradiol levels in men are not risk factors for coronary artery disease (CAD) (Iranian Heart Journal 2002, 2003; 3(4&4(1): 71-73).