HAMEDAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, HAMEDAN, IRAN
Abstract
Background: Coronary artery disease (CAD) is one of the most common health problems facing health care services in all societies. Despite the established significance of the classic risk factors for CAD, a large number of patients present without them. It has recently been identified that elevated inflammatory markers and involved immunological mechanisms are associated with atherosclerosis. CD 28 is the main co-stimulatory receptor for secondary signals delivering for T-cell activation. The aim of this study was to evaluate the polymorphism of CD 28 gene as a probable risk factor for CAD. Methods: In total, 200 patients were classified into two equal groups: control group including persons with normal coronary arteries and case group who had at least single-vessel coronary disease. CAD was confirmed in the studied patients by coronary angiography. CD 28 genotype was analyzed via polymerase chain reaction (PCR). Results: The frequencies of C and T alleles were 71% and 29% in the control group and 70.5% and 29.5% in the case group, respectively. There was no significant difference in the allele frequencies between the two groups. Conclusion: We concluded that CD 28 gene polymorphism was not associated with CAD.
MADANI, M., NAGHSH TABRIZI, B., HAJILOUEI, M., SEYF RABIEI,, M., ZAHED MEHR, A., & AMIRASLANI, R. (2008). CD 28 GENE POLYMORPHISM IS NOT ASSOCIATED WITH SUSCEPTIBILITY TO CORONARY ARTERY DISEASE. Iranian Heart Journal, 9(4), 38-41.
MLA
M. MADANI; B. NAGHSH TABRIZI; M. HAJILOUEI; M.A. SEYF RABIEI,; A. ZAHED MEHR; R. AMIRASLANI. "CD 28 GENE POLYMORPHISM IS NOT ASSOCIATED WITH SUSCEPTIBILITY TO CORONARY ARTERY DISEASE". Iranian Heart Journal, 9, 4, 2008, 38-41.
HARVARD
MADANI, M., NAGHSH TABRIZI, B., HAJILOUEI, M., SEYF RABIEI,, M., ZAHED MEHR, A., AMIRASLANI, R. (2008). 'CD 28 GENE POLYMORPHISM IS NOT ASSOCIATED WITH SUSCEPTIBILITY TO CORONARY ARTERY DISEASE', Iranian Heart Journal, 9(4), pp. 38-41.
VANCOUVER
MADANI, M., NAGHSH TABRIZI, B., HAJILOUEI, M., SEYF RABIEI,, M., ZAHED MEHR, A., AMIRASLANI, R. CD 28 GENE POLYMORPHISM IS NOT ASSOCIATED WITH SUSCEPTIBILITY TO CORONARY ARTERY DISEASE. Iranian Heart Journal, 2008; 9(4): 38-41.