DEPT. OF CARDIOLOGY, BABOL FACULTY OF MEDICINE, BABOL UNIVERSITY OF MEDICAL SCIENCES, BABOL, IRAN
Background: Coronary artery disease (CAD) usually occurs in the middle age group. However, recently a significant proportion of this disease occurs in young patients aged less than 45 years. There is still controversy whether the young patients have a high prevalence of some risk factors and whether their nature of disease is more aggressive. This study compared the profile of distribution of major risk factors between patients aged less or older than 45 years of age with acute myocardial infarction.
Methods: We conducted a cross-sectional study based on hospital charts of 1236 patients with diagnosis of myocardial infarction who were hospitalized consecutively at our department between 1991 and 2001. The data of age, gender and major risk factors such as diabetes mellitus, hypercholesterolemia, hypertriglyceridemia, hypertension and smoking status were collected using hospital charts.
Results: The results showed that out of the 1236 cases, 105 (8.5%) occurred in patients aged less than 45 years (10.5% of the males and 5.3% of the females, P=0.03). Overall, 62% of the patients were male and 38% female. Among major risk factors studied, the prevalence of smoking and hypertriglyceridemia was more common in the less-than-45-year-old age group in comparison with the second group (42.2% vs. 29.7%, P=0.009 and 17.7% vs.10.4%, P=0.03), respectively. We did not find a significant difference in the prevalence of hypertension (27.5% vs. 29.3%, P=0.7) and hypercholesterolemia between the two age groups under study (45.8% vs. 42.9%, P=0.57), but diabetes mellitus was more common in the older age group (15.5% vs. 24.8%, P=0.03).
Conclusion: The results indicated that smoking and hypertriglyceridemia were more common among MI patients aged less than 45 years compared to the above-45-year-old age group. Thus, the implications of these findings are to apply further intervention programs for the prevention of risk factors in young adults.