Iranian Heart Association Iranian Heart Journal 21 2 2020 04 01 Transfusion of Blood Components and Postoperative Outcomes in Patients Undergoing Cardiac Surgery 64 70 105529 EN Zahra Faritous Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, IR Iran. Fatemeh Yaghouti Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, IR Iran. Behshid Ghadrdoost Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, IR Iran. 0000-0002-8876-5133 Evaz Heidarpour Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, IR Iran. Mohsen Ziyaeifard Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, IR Iran. Journal Article 2019 07 09 Background: Blood transfusion is needed in patients following open-heart surgery; however, it may lead to the incidence of infection, increased mortality, and longer hospitalization. This study was designed to evaluate the outcome of blood transfusion in patients who underwent cardiac surgery.<br />Methods: The present study enrolled 784 candidates for open-heart surgery at our tertiary care center between April 2012 and 2013. The study outcomes were defined as sepsis, mediastinitis, pneumonia, mortality, extubation times more than 8 hours after surgery, and intensive care unit (ICU) lengths of stay of more than 3 days.<br />Results: There was a significant association between packed cell transfusion and the incidence of pneumonia, sepsis, prolonged intubation times, surgical site infections, and prolonged lengths of ICU and hospital stay (P < 0.05); however, there was no significant association between packed cell transfusion and mortality (P = 0.2). There was a significant relationship between fresh frozen plasma transfusion and the incidence of all types of surgical complications, mortality, and prolonged ICU and hospital lengths of stay (P < 0.05).<br />There was a significant association between platelet transfusion and the incidence of pneumonia, mediastinitis, prolonged intubation times, surgical site infections, and prolonged lengths of ICU and hospital stay (P < 0.05); nonetheless, there was no significant association between platelet transfusion and mortality (P= 0.1). In the multiple logistic regression, an association was observed between age, sex, and complications following adjustments for packed cell transfusion, fresh frozen plasma, and platelet.<br />Conclusions: The administration of blood and hemo-components was associated with the development of postoperative complications such as sepsis, mediastinitis, pneumonia, mortality, prolonged intubating times, and prolonged lengths of ICU and hospital stay. (Iranian Heart Journal 2020; 21(2): 64-70) https://journal.iha.org.ir/article_105529_083de0c93add0a646b1b2ef06c476a88.pdf