Iranian Heart Association Iranian Heart Journal 22 2 2021 04 01 Protective Effects of N-Acetyl Cysteine on Cardiac Function in Diabetic Patients Undergoing Coronary Artery Bypass Grafting 96 100 128485 EN Ahmad Reza Salimbahrami Hamadan University of Medical Sciences, Hamadan, IR Iran. Amir Hossein Yazdi Hamadan University of Medical Sciences, Hamadan, IR Iran. 0000-0003-1235-1433 Leila Najm Afshar Hamadan University of Medical Sciences, Hamadan, IR Iran. Zahra Mohammadzade-Vizhe Department of Anesthesia, Khatam-ol-Anbia Hospital of Miane, Tabriz University of Medical Sciences, Tabriz, IR Iran. Mohammad Hossein Bakhshaei Hamadan University of Medical Sciences, Hamadan, IR Iran. 0000-0002-3820-2447 Maryam Farhadian Department of Biostatics, School of Public Health and Research Center for Health Sciences, Hamadan University of Medical Sciences, Hamadan, IR Iran. 0000-0002-6054-9850 Journal Article 2020 04 08 <strong><em>Background:</em></strong> The preservation of cardiac function in diabetic patients undergoing coronary artery bypass grafting (CABG) would result in improved prognoses in patients. Therefore, in this study, the protective effects of N-acetyl cysteine (NAC) on cardiac function in diabetic patients undergoing CABG were determined.   <strong><em>Methods:</em></strong> This triple-blind, randomized, clinical trial study recruited 240 consecutive diabetic patients undergoing CABG in a referral tertiary health-care center, Hamadan, Iran. The patients were randomly assigned (simple random sampling) to receive either NAC or a placebo. In both groups, ischemic preconditioning was developed with a manometer cuff around the arm. The cuff was filled up to 200 mm Hg for 5 minutes before it was emptied to 0 mm Hg for 5 minutes. This technique was repeated 3 times.   <strong><em>Results: </em></strong>The mean preoperative ejection fraction (EF) and the preoperative myocardial performance index (MPI) were the same in the 2 groups (<em>P</em>>0.05). The postoperative EF and the MPI were not significantly different between the 2 groups (<em>P</em>>0.05). The trend of changes in the EF and the MPI was not different between the groups (<em>P</em>>0.05).   <strong><em>Conclusions: </em></strong>This study demonstrated that NAC in the ischemic preconditioning method did not create a significant effect compared with a placebo, which is in congruence with previous studies in animal models. <strong><em>(Iranian Heart Journal 2021; 22(2): 96-100)</em></strong> https://journal.iha.org.ir/article_128485_5123265d40dd9872742ebc5ba80b1a66.pdf