Iranian Heart Association Iranian Heart Journal 23 1 2022 01 01 Intravenous Vitamin C to Prevent Contrast-Induced Nephropathy in Patients Undergoing Percutaneous Coronary Intervention 149 159 142609 EN Farzaneh Futuhi Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran. Mahshid Malakootian Cardiogenetic Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran. Majid Maleki Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran. Mohammad Mehdi Peighambari Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran. Maryam Hosseini Moghadam Cardiogenetic Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran. Mohammad Javad Hosseini Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran. Shabnam Boudagh Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran. 0000-0001-7218-9111 Maedeh Arabian Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran. Journal Article 2020 10 18 <strong><em>Background:</em></strong> This retrospective cohort study aimed to evaluate the effects of the intravenous administration of vitamin C before and after exposure to the contrast medium for the prophylaxis of contrast-induced nephropathy (CIN) in patients undergoing coronary angiography.<br /> <br /><strong><em>Methods:</em></strong> Data on 210 patients with chronic kidney disease (CKD) (defined as an estimated glomerular filtration rate ≤60 mL/min/1.73m²) were obtained through medical chart reviews and electronic data<strong> </strong>in 3 different groups: 1) no vitamin C administered, 2) vitamin C administered 30 minutes before angiography, and 3) vitamin C administered 30 minutes after angiography. Each group consisted of 70 patients, and vitamin C was administered intravenously. CIN incidence in all the groups was defined as an increase of 0.5 mg/dL or 25% in serum creatinine levels.<br /> <br /><strong><em>Results: </em></strong>Overall, CIN incidence was significantly lower in patients who received intravenous vitamin C before (<em>P</em>≤0.05) and after (<em>P</em>≤0.05) angiography than in patients with no prophylaxis. The post-angiography administration of vitamin C was very effective in diminishing creatinine rise and preventing CIN. CIN occurred in 7.1% of the patients in the pre-administered and post-administered groups.<br /> <br /><strong><em>Conclusions: </em></strong>The intravenous administration of vitamin C before and after angiography could effectively decrease CIN incidence in patients undergoing percutaneous coronary intervention. The post-angiography administration of vitamin C is more effective to decrease serum creatinine levels.<strong><em> </em></strong><strong><em>(Iranian Heart Journal 2022; 23(1): 149-159)</em></strong> https://journal.iha.org.ir/article_142609_78f3dca788bbf2e8bd6bdb632510e7d6.pdf